公开(公告)号：US11470828B2

公开(公告)日：2022-10-18

申请号：US16744493

申请日：2020-01-16

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/72

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.

公开(公告)号：US20230123787A1

公开(公告)日：2023-04-20

申请号：US17818730

申请日：2022-08-10

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/72

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.

公开(公告)号：US20200229409A1

公开(公告)日：2020-07-23

申请号：US16744493

申请日：2020-01-16

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.

公开(公告)号：US20190032156A1

公开(公告)日：2019-01-31

申请号：US16050822

申请日：2018-07-31

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Guochun Gong ,  Charleen Hunt ,  Suzanne Hartford ,  Jose Rojas ,  David Frendewey ,  Brian Zambrowicz ,  Andrew J. Murphy

IPC: C12Q1/6897 ,  A01K67/027 ,  C12N9/38 ,  A61K49/00 ,  C12N15/11 ,  C12N9/22

Abstract: Methods and compositions are provided for assessing CRISPR/Cas-induced recombination of a target genomic locus with an exogenous donor nucleic acid in vivo or ex vivo. The methods and compositions employ non-human animals comprising a CRISPR reporter such as a genomically integrated CRISPR reporter for detecting and measuring CRISPR/Cas-induced repair of a coding sequence for a catalytically inactive reporter protein through recombination with an exogenous donor nucleic acid. Methods and compositions are also provided for making and using these non-human animals.