公开(公告)号：US3925399A

公开(公告)日：1975-12-09

申请号：US46518874

申请日：1974-04-29

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  LE MARTRET ODILE

IPC: A61K31/425 ,  C07D277/56 ,  C07F5/06

Abstract: The basic aluminum salt of 2-n-propyl-5-thiazolecarboxylic acid having the formula

ITS PREPARATION, HYPOLIPEMIANT COMPOSITIONS CONTAINING THE SAME AND THERAPEUTIC METHODS TO TREAT HYPERLIPEMIA UTILIZING THE HYPOLIPEMIANT COMPOSITIONS.

Abstract translation: 具有式ITS的2-正丙基-5-噻唑甲酸的碱性铝盐，其含有其的高效组合物和治疗使用高效组合物的治疗方法。

公开(公告)号：US3903114A

公开(公告)日：1975-09-02

申请号：US40203073

申请日：1973-10-01

Applicant: ROUSSEL UCLAF

Inventor： LE MARTRET ODILE ,  CLEMENCE FRANCOIS

IPC: A61K31/38 ,  A61K31/381 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  C07D333/22 ,  C07D333/38

CPC classification number: C07D333/22

Abstract: Novel thiophene derivatives of the formula

WHEREIN R and R2 are individually selected from the group consisting of hydrogen and methyl with R2 being in the 3- or 4position of the thienyl ring, R1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and X is selected from the group consisting of hydrogen, halogen, methyl, methoxy, CF3- and CF3O- in any position on the benzene ring, the compounds being in racemic or optically active form when R is methyl having anti-inflammatory and analgesic activity.

Abstract translation: 式WHEREIN R和R2的新型噻吩衍生物分别选自氢和甲基，R2在噻吩环的3-或4-位，R1选自氢和酰基， 1至18个碳原子的有机羧酸，X选自氢，卤素，甲基，甲氧基，CF3-和CF3O-在苯环上的任何位置，该化合物当R 是具有抗炎和止痛活性的甲基。

公开(公告)号：US3882110A

公开(公告)日：1975-05-06

申请号：US43188174

申请日：1974-01-09

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  LE MARTRET ODILE

IPC: A61K31/425 ,  C07D277/56 ,  C07D91/32

CPC classification number: A61K31/425 ,  C07D277/56

Abstract: WHEREIN R has the above-assigned meaning and R''1 is a linear alkyl of 1 to 12 carbon atoms.

WHEREIN R is hydrogen, an alkali metal, ammonium, the monovalent residue of an organic amine base or a substituted or unsubstituted alkyl and R'' is a linear alkyl of 3 to 12 carbon atoms, and their preparation, and hypolipemiant compositions containing at least one 2-alkyl-5-thiazole carboxylic acid derivative of the formula

2-Alkyl-5-thiazole carboxylic acid derivatives of the formula

Abstract translation: 2-烷基-5-噻唑羧酸衍生物，式为WHEREIN R为氢，碱金属，铵，有机胺碱的单价残基或取代或未取代的烷基，R'为3至12碳的直链烷基 原子及其制备方法，以及含有至少一种下式WHEREIN R具有上述含义的2-烷基-5-噻唑羧酸衍生物的低胆固醇组合物，R'1是1至12个碳原子的直链烷基。

公开(公告)号：US3872124A

公开(公告)日：1975-03-18

申请号：US34028973

申请日：1973-03-12

Applicant: ROUSSEL UCLAF

Inventor： LE MARTRET ODILE ,  CLEMENCE FRANCOIS

IPC: C07D295/13 ,  A61K20060101 ,  A61K31/425 ,  A61K31/495 ,  C07D20060101 ,  C07D277/20 ,  C07D277/56 ,  C07D295/096 ,  C07D417/12 ,  C07D51/70

CPC classification number: C07D295/13 ,  C07D277/56

Abstract: Novel thiazolcarboxamides of the formula

D R A W I N G
WHEREIN R is selected from the group consisting of alkyl of 1 to 6 carbon atoms and phenyl, R1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, n is a whole number from 2 to 5 and X and X1 are individually selected from the group consisting of hydrogen, halogen, trifluoromethyl and alkyl, alkoxy and alkylthio of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having Alpha -adrenolytic activity and their preparation.

Abstract translation: 式WHEREIN R的新型噻唑甲酰胺选自1至6个碳原子的烷基和苯基，R 1选自氢和1至4个碳原子的烷基，n是从2到 5和X和X 1分别选自氢，卤素，三氟甲基和具有1至4个碳原子的烷基，烷氧基和烷硫基及其无毒的药学上可接受的具有α-脱水活性的酸加成盐及其制备。