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公开(公告)号：US06660732B2
公开(公告)日：2003-12-09
申请号：US09962709
申请日：2001-09-25
申请人： Rajashehar Betageri , Steffen Breitfelder , Pier F. Cirillo , Thomas A. Gilmore , Eugene R. Hickey , Thomas M. Kirrane , Monica H. Moriak , Neil Moss , Usha R. Patel , John R. Proudfoot , John R. Regan , Rajiv Sharma , Sanxing Sun , Alan D. Swinamer , Hidenori Takahashi
发明人： Rajashehar Betageri , Steffen Breitfelder , Pier F. Cirillo , Thomas A. Gilmore , Eugene R. Hickey , Thomas M. Kirrane , Monica H. Moriak , Neil Moss , Usha R. Patel , John R. Proudfoot , John R. Regan , Rajiv Sharma , Sanxing Sun , Alan D. Swinamer , Hidenori Takahashi
IPC分类号： A61K315377
CPC分类号： C07D213/74 , C07D213/38 , C07D213/76 , C07D231/38 , C07D307/12 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D493/08 , C07D495/08
摘要： Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
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公开(公告)号：US07019006B2
公开(公告)日：2006-03-28
申请号：US10624289
申请日：2003-07-21
申请人： Pier F. Cirillo , Steffen Breitfelder , Usha R. Patel , John R. Proudfoot , Alan D. Swinamer , Hidenori Takahashi , Thomas A. Gilmore , Rajiv Sharma
发明人： Pier F. Cirillo , Steffen Breitfelder , Usha R. Patel , John R. Proudfoot , Alan D. Swinamer , Hidenori Takahashi , Thomas A. Gilmore , Rajiv Sharma
IPC分类号： C07D413/02 , A61K31/47
CPC分类号： C07D213/74 , C07D213/38 , C07D213/76 , C07D231/38 , C07D307/12 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D493/08 , C07D495/08
摘要： Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
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公开(公告)号：US06358945B1
公开(公告)日：2002-03-19
申请号：US09505582
申请日：2000-02-16
申请人： Steffen Breitfelder , Pier F. Cirillo , Thomas A. Gilmore , Eugene R. Hickey , John R. Proudfoot , John R. Regan , Alan D. Swinamer , Hidenori Takahashi
发明人： Steffen Breitfelder , Pier F. Cirillo , Thomas A. Gilmore , Eugene R. Hickey , John R. Proudfoot , John R. Regan , Alan D. Swinamer , Hidenori Takahashi
IPC分类号： A61K315377
CPC分类号： C07D213/74 , C07D213/38 , C07D213/76 , C07D231/38 , C07D307/12 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D493/08 , C07D495/08
摘要： Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
摘要翻译： 公开了可用于治疗涉及炎症的疾病或病理状况的新型芳族化合物，例如慢性炎性疾病。 还公开了含有制备这些化合物的药物组合物和方法。
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公开(公告)号：US06492393B1
公开(公告)日：2002-12-10
申请号：US09714539
申请日：2000-11-16
申请人： Steffen Breitfelder , Pier F. Cirillo , Ming-Hong Hao , Eugene R. Hickey , Rajiv Sharma , Sanxing Sun , Hidenori Takahashi
发明人： Steffen Breitfelder , Pier F. Cirillo , Ming-Hong Hao , Eugene R. Hickey , Rajiv Sharma , Sanxing Sun , Hidenori Takahashi
IPC分类号： A61K31445
CPC分类号： C07D207/404 , C07C275/34 , C07C323/44 , C07C2601/02 , C07D211/74 , C07D213/30 , C07D213/38 , C07D213/66 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D215/46 , C07D231/12 , C07D233/56 , C07D233/64 , C07D239/42 , C07D249/08 , C07D265/30 , C07D265/36 , C07D295/088 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/185 , C07D307/14 , C07D309/06 , C07D309/12 , C07D333/48 , C07D401/06 , C07D405/12 , C07D413/12 , C07D471/04
摘要： Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
摘要翻译： 公开了式（I）的新型芳族化合物，其中G，X，Ar，L和Q在本文中定义。 该化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。 还公开了制备这些化合物的方法。
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公开(公告)号：US07026476B2
公开(公告)日：2006-04-11
申请号：US10424613
申请日：2003-04-28
IPC分类号： C07D265/30 , C07D413/00 , C07D401/00 , C07D421/00 , C07D409/00
CPC分类号： C07D213/74 , C07D213/38 , C07D213/76 , C07D231/38 , C07D307/12 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D493/08 , C07D495/08
摘要： Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.
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公开(公告)号：US06608052B2
公开(公告)日：2003-08-19
申请号：US09834797
申请日：2001-04-13
IPC分类号： A61K315377
CPC分类号： C07D401/12 , C07D213/38 , C07D307/12 , C07D307/52 , C07D405/12 , C07D409/12
摘要： Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
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7.发明授权Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists 有权苯并恶唑和四氢苯并恶唑取代的哒嗪酮作为GPR119激动剂公开(公告)号：US08772323B2
公开(公告)日：2014-07-08
申请号：US13696094
申请日：2011-05-06
申请人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
发明人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
IPC分类号： A61K31/423 , C07D263/54
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的哒嗪酮衍生物，其中基团A，G和R 1如本申请中所定义，其互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质， 特异性结合GPR119受体并调节其活性。
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公开(公告)号：US20100099680A1
公开(公告)日：2010-04-22
申请号：US12524791
申请日：2008-01-28
申请人： Riccardo Giovannini , Sara Frattini , Trixi Brandl , Steffen Breitfelder , Enzo Cereda , Matthias Grauert , Matthias Hoffmann , Anne T. Joergensen , Udo Maier , Alexander Pautsch , Monica Quai , Stefan Scheuerer
发明人： Riccardo Giovannini , Sara Frattini , Trixi Brandl , Steffen Breitfelder , Enzo Cereda , Matthias Grauert , Matthias Hoffmann , Anne T. Joergensen , Udo Maier , Alexander Pautsch , Monica Quai , Stefan Scheuerer
IPC分类号： A61K31/519 , C07D475/00 , A61P29/00 , A61P37/08 , A61P11/00
CPC分类号： C07D487/04
摘要： New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
摘要翻译： 提供式（1）的新化合物，其由于其药物活性，因为PI3-激酶调节剂可用于治疗炎症或过敏性疾病的治疗领域。 这些实例包括炎性和过敏性呼吸道疾病，胃肠道炎症性疾病和运动器官，炎性和过敏性皮肤疾病，炎症性眼病，鼻粘膜疾病，涉及自身免疫反应或炎症的炎性或过敏性疾病 。
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公开(公告)号：US07517995B2
公开(公告)日：2009-04-14
申请号：US11690356
申请日：2007-03-23
申请人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： C07D513/04
摘要： Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1，R 2，R a和R b具有权利要求书和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映异构体及其混合物，以及任选的药理学可接受的酸加成 盐，溶剂合物和水合物，以及制备这些噻唑基 - 二氢环戊吡唑的方法及其作为药物组合物的用途。
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公开(公告)号：US07041674B2
公开(公告)日：2006-05-09
申请号：US10718403
申请日：2003-11-20
IPC分类号： A61K31/46 , C07D491/08
CPC分类号： C07D451/06
摘要： A compound of formula 1 wherein X−, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in pharmaceutical compositions, and methods of treating patients using them.
摘要翻译： 式1的化合物，其中X，O，A，R 1，R 2，R 3和R 3， 可以具有权利要求书和说明书中给出的含义，其制备方法，它们在药物组合物中的用途，以及使用它们治疗患者的方法。
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