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公开(公告)号:US08383093B1
公开(公告)日:2013-02-26
申请号:US13524994
申请日:2012-06-15
申请人: Randall Moreadith , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas
发明人: Randall Moreadith , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas
IPC分类号: A61K31/00
CPC分类号: A61K47/48192 , A61K9/0019 , A61K31/381 , A61K31/4045 , A61K31/4462 , A61K31/4535 , A61K31/4745 , A61K31/7048 , A61K47/542 , A61K47/60 , A61K47/61
摘要: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
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公开(公告)号:US6103523A
公开(公告)日:2000-08-15
申请号:US810945
申请日:1997-02-27
申请人: Randall Moreadith , Luc Schoonjans
发明人: Randall Moreadith , Luc Schoonjans
IPC分类号: C12N5/02 , C12N5/073 , C12N5/0735 , C12N15/877 , C12N5/00 , C12N9/66
CPC分类号: C12N15/8771 , C12N15/8777 , C12N5/0603 , C12N5/0606 , C12N2501/235 , C12N2501/33 , C12N2502/13 , C12N2509/00
摘要: The present invention relates to a rabbit embryonic stem (ES) cell line, comprising at least 70%, preferably 80 to 90% undifferentiated cells and obtainable by isolating the inner cell mass of 5.5 days postcoitus blastocysts and culturing them on feeder cells in rabbit ES medium. The invention further relates to further optimization of derivation and maintainance of the cell line and to the use thereof in inter alia generation of chimeric rabbits.
摘要翻译: 本发明涉及兔胚胎干(ES)细胞系,其包含至少70%,优选80-90%的未分化细胞,并且可通过分离后肠胚泡的5.5天的内细胞块并在兔ES中的饲养细胞上培养 中。 本发明进一步涉及进一步优化细胞系的衍生和维持性,以及其特别是产生嵌合兔的用途。
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