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公开(公告)号：US20120171780A1
公开(公告)日：2012-07-05
申请号：US13382646
申请日：2010-06-30
IPC分类号： G01N21/64
CPC分类号： G01N21/77 , G01N21/6428 , G01N2021/6432 , G01N2021/7786
摘要： The apparatus of the present invention comprises a fluorescent polymer contained within a solid-phase extraction (SPE) carrier. The fluorescent polymer is capable of adsorbing an analyte by means of functional monomers. In use of the apparatus, a sample, such as a foodstuff sample, is applied to the fluorescent polymer. If the sample comprises the analyte, adsorption of the analyte onto the fluorescent polymer causes quenching of the fluorescence of the fluorescent polymer. Fluorescence quenching can be detected using a fluorometer or transillumination system. The method can be used to determine whether mycotoxins are present in foodstuff samples.
摘要翻译： 本发明的装置包含在固相萃取（SPE）载体中的荧光聚合物。 荧光聚合物能够通过官能单体吸附分析物。 在使用该装置时，将诸如食品样品的样品施加到荧光聚合物上。 如果样品包含分析物，则将分析物吸附到荧光聚合物上导致荧光聚合物的荧光猝灭。 可以使用荧光计或透照系统检测荧光淬灭。 该方法可用于确定霉菌毒素是否存在于食品样品中。
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公开(公告)号：US20100151583A1
公开(公告)日：2010-06-17
申请号：US12596542
申请日：2008-04-17
IPC分类号： C08F120/06 , C08F20/56 , C08J9/26 , C07D311/04 , B01D15/00 , G01N33/00
CPC分类号： B01J20/267 , B01D15/00 , B01D15/08 , B01J20/261 , B01J20/264 , Y10T436/142222
摘要： Polymers capable of binding ochratoxins are disclosed. The polymers may be used for solid phase extraction of ochratoxins and immobilisation of ochratoxins in solid phase extraction (SPE) cartridges, for qualitative or quantitative analysis of ochratoxins in liquid extracts from foodstuffs or animal feeds. The polymers may be prepared from monomers containing amido or amino-alkyl moieties and acid moieties. Preferred embodiments are polymers prepared from 2-acrylamido-2-methylpropane-sulfonic acid (AMPSA) and from a mixture of diethyl aminoethyl methacrylate (DEAEM) and itaconic acid (IA). The polymers are preferably cross-linked, for example using ethylene glycol dimethacrylate (EGDMA) or divinyl benzene (DVB), and made macroporous by polymerisation in the presence of a porogen solvent such as dimethyl formamide (DMF).
摘要翻译： 公开了能够结合赭曲霉毒素的聚合物。 聚合物可用于赭曲霉毒素的固相萃取和固相萃取（SPE）柱中赭曲霉毒素的固定，用于定量或定量分析来自食品或动物饲料的液体提取物中的赭曲霉毒素。 聚合物可以由含有酰氨基或氨基 - 烷基部分和酸部分的单体制备。 优选的实施方案是由2-丙烯酰氨基-2-甲基丙烷 - 磺酸（AMPSA）和二乙基氨基乙基甲基丙烯酸酯（DEAEM）和衣康酸（IA）的混合物制备的聚合物。 聚合物优选是交联的，例如使用乙二醇二甲基丙烯酸酯（EGDMA）或二乙烯基苯（DVB）），并通过在诸如二甲基甲酰胺（DMF）的致孔剂溶剂存在下进行聚合而制成大孔。
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公开(公告)号：US20120270335A1
公开(公告)日：2012-10-25
申请号：US13391706
申请日：2010-08-26
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01D15/08 , B01J20/26 , B01J20/261 , B01J20/267 , B01J2220/49 , B01J2220/62 , B01J2220/64 , G01N1/405
摘要： Apparatus, methods and polymers for solid phase extraction by binding an analyte containing a primary amino group. The polymer is a reactive polymer, wherein binding of the analyte to the polymer causes fluorescent isoindole complex formation. A method of binding comprises use of an SPE carrier, such as an SPE cartridge, loaded with a reactive polymer. Binding of an analyte is detected by observing changes in fluorescence after applying the analyte to the polymer. Fluorescence can be detected using a fluorometer or transilluminator, for example. In a preferred embodiment, the reactive polymer is prepared from a monomer mixture comprising acetonitrile and triethylamine.
摘要翻译： 通过结合含有伯氨基的分析物进行固相萃取的装置，方法和聚合物。 聚合物是反应性聚合物，其中分析物与聚合物的结合导致荧光异吲哚络合物形成。 一种结合的方法包括使用装载有反应性聚合物的SPE载体，例如SPE柱。 通过在将分析物施加到聚合物之后观察荧光的变化来检测分析物的结合。 例如，可以使用荧光计或透照器来检测荧光。 在优选的实施方案中，反应性聚合物由包含乙腈和三乙胺的单体混合物制备。
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4.发明授权Apparatus and method for detection and measurement of target compounds such as a food toxin 有权用于检测和测量目标化合物如食物毒素的装置和方法公开(公告)号：US08344334B2
公开(公告)日：2013-01-01
申请号：US12681863
申请日：2008-09-22
IPC分类号： G01N21/64
CPC分类号： G01N21/65 , G01N21/64 , G01N21/658 , G01N33/02 , G01N2021/651 , G01N2021/656 , G01N2201/129
摘要： A method for the detection or determination of a target comprising a plurality of target compounds, or derivatised target compounds, said method comprising: immobilizing said target on a carrier, directing radiation at said target, said radiation being selected to cause said target to emit a relevant radiation, detecting said relevant radiation emitted by said target, and analyzing said detected radiation to identify and/or quantify the plurality of target compounds in said target.
摘要翻译： 一种用于检测或测定包含多种目标化合物或衍生化的靶化合物的靶的方法，所述方法包括：将所述靶固定在载体上，引导所述靶上的辐射，选择所述辐射使所述靶发射 相关辐射，检测由所述目标发射的相关辐射，并分析所述检测到的辐射以识别和/或定量所述靶中的多个目标化合物。
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5.发明授权Device for detection and measurement of a target compound such as a food toxin 有权用于检测和测量诸如食物毒素的目标化合物的装置公开(公告)号：US07843566B2
公开(公告)日：2010-11-30
申请号：US11914841
申请日：2006-05-19
IPC分类号： G01N21/25
CPC分类号： G01N21/645 , G01N2021/6432
摘要： Apparatus comprising a holder for a sample which comprises a packing or coating capable of immobilising or isolating a target compound in a layer or band, an excitation unit that emits radiation that excites fluorescence in a target compound or derivatised target compound immobilised or isolated in the packing or coating, or in another moiety stimulated by the target compound, a detection unit that is sensitive to radiation emitted by a fluorescing target compound, derivative or target compound-stimulated moiety and outputs a signal proportional to the amount of radiation detected, means for relatively moving the sample cartridge and the detection unit whereby the radiation may be sensed and a processing unit that converts the output of the detector unit into a readable value related to the amount of target compound immobilised in the layer or band.
摘要翻译： 包括用于样品的保持器的装置，其包括能够固定或分离层或带中的目标化合物的填料或涂层，激发单元，其发射在目标化合物中激发荧光的激发单元或在所述包装中固定或分离的衍生化目标化合物 或涂层，或在目标化合物刺激的另一部分中，检测单元对荧光目标化合物，衍生物或目标化合物刺激的部分发射的辐射敏感，并输出与所检测的辐射量成比例的信号，相对于 移动样品盒和检测单元，从而可以感测辐射;以及处理单元，其将检测器单元的输出转换成与固定在层或带中的目标化合物的量相关的可读值。
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6.发明申请APPARATUS AND METHOD FOR DETECTION AND MEASUREMENT OF TARGET COMPOUNDS SUCH AS A FOOD TOXIN 有权用于食物毒素的目标化合物的检测和测量的装置和方法公开(公告)号：US20100264332A1
公开(公告)日：2010-10-21
申请号：US12681863
申请日：2008-09-22
CPC分类号： G01N21/65 , G01N21/64 , G01N21/658 , G01N33/02 , G01N2021/651 , G01N2021/656 , G01N2201/129
摘要： A method for the detection or determination of a target comprising a plurality of target compounds, or derivatised target compounds, said method comprising: immobilising said target on a carrier, directing radiation at said target, said radiation being selected to cause said target to emit a relevant radiation, detecting said relevant radiation emitted by said target, and analysing said detected radiation to identify and/or quantify the plurality of target compounds in said target.
摘要翻译： 一种用于检测或确定包含多种目标化合物或衍生化的靶化合物的靶的方法，所述方法包括：将所述靶固定在载体上，引导所述靶上的辐射，所述辐射被选择以使所述靶发射 相关辐射，检测由所述目标发射的相关辐射，并分析所述检测到的辐射以识别和/或定量所述靶中的多个目标化合物。
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7.发明申请Device For Detection And Measurement Of A Target Compound Such As A Food Toxin 有权用于检测和测量作为食物毒素的目标化合物的装置公开(公告)号：US20080198379A1
公开(公告)日：2008-08-21
申请号：US11914841
申请日：2006-05-19
IPC分类号： G01J3/30
CPC分类号： G01N21/645 , G01N2021/6432
摘要： Apparatus comprising a holder for a sample which comprises a packing or coating capable of immobilising or isolating a target compound in a layer or band, an excitation unit that emits radiation that excites fluorescence in a target compound or derivatised target compound immobilised or isolated in the packing or coating, or in another moiety stimulated by the target compound, a detection unit that is sensitive to radiation emitted by a fluorescing target compound, derivative or target compound-stimulated moiety and outputs a signal proportional to the amount of radiation detected, means for relatively moving the sample cartridge and the detection unit whereby the radiation may be sensed and a processing unit that converts the output of the detector unit into a readable value related to the amount of target compound immobilised in the layer or band.
摘要翻译： 包括用于样品的保持器的装置，其包括能够固定或分离层或带中的目标化合物的填料或涂层，激发单元，其发射在目标化合物中激发荧光的激发单元或在所述包装中固定或分离的衍生化目标化合物 或涂层，或在目标化合物刺激的另一部分中，检测单元对荧光目标化合物，衍生物或目标化合物刺激的部分发射的辐射敏感，并输出与所检测的辐射量成比例的信号，相对于 移动样品盒和检测单元，从而可以感测辐射;以及处理单元，其将检测器单元的输出转换成与固定在层或带中的目标化合物的量相关的可读值。
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