-
公开(公告)号:US5665865A
公开(公告)日:1997-09-09
申请号:US343658
申请日:1994-11-22
申请人: Richard A. Lerner , Victoria A. Roberts , Elizabeth D. Getzoff , John A. Tainer , Stephen J. Benkovic
发明人: Richard A. Lerner , Victoria A. Roberts , Elizabeth D. Getzoff , John A. Tainer , Stephen J. Benkovic
IPC分类号: A61K39/395 , C07K14/00 , C07K16/00 , C07K19/00 , C12N1/21 , C12N9/00 , C12N15/09 , C12P21/00 , C12P21/08 , C12R1/19 , G01N33/53
CPC分类号: C12N9/0002 , C07K16/00
摘要: The invention describes a metal binding protein capable of forming a coordination complex with a metal cation. The protein contains a sequence of amino acid residues that defines a variable domain of an immunoglobulin light chain having a L1 region and a L3 region, and also contains three contact amino acid residues in the variable domain that participate as ligands for the metal coordination complex.
摘要翻译: 本发明描述了能够与金属阳离子形成配位络合物的金属结合蛋白。 蛋白质含有限定具有L1区域和L3区域的免疫球蛋白轻链可变结构域的氨基酸残基序列,并且在可变结构域中还含有参与作为金属配位络合物配体的三个接触氨基酸残基。