公开(公告)号：US12013405B2

公开(公告)日：2024-06-18

申请号：US17510459

申请日：2021-10-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82 ,  C07C401/00

CPC classification number: G01N33/82 ,  C07C401/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

公开(公告)号：US11415576B2

公开(公告)日：2022-08-16

申请号：US15614856

申请日：2017-06-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Elke Faatz ,  Michael Gerg ,  Hans-Peter Josel ,  Christian Vogl

IPC: G01N33/537 ,  C07K16/26 ,  G01N33/82 ,  G01N33/541

Abstract: The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.

公开(公告)号：US20160025750A1

公开(公告)日：2016-01-28

申请号：US14874702

申请日：2015-10-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  C07C401/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

公开(公告)号：US20160245829A1

公开(公告)日：2016-08-25

申请号：US15144172

申请日：2016-05-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  C07C401/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

Abstract translation: 用于释放与维生素D结合蛋白结合的维生素D化合物的试剂组合物和用于检测维生素D化合物的体外方法，其中维生素D化合物通过使用该试剂组合物从维生素D结合蛋白中释放出来 以及以这种方式获得的试剂混合物。 还公开了试剂组合物用于释放维生素D化合物以及用于检测维生素D化合物的试剂盒的用途。

公开(公告)号：US20170269068A1

公开(公告)日：2017-09-21

申请号：US15614856

申请日：2017-06-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Elke Faatz ,  Michael Gerg ,  Hans-Peter Josel ,  Christian Vogl

IPC: G01N33/537 ,  G01N33/82 ,  C07K16/26 ,  G01N33/541

CPC classification number: G01N33/537 ,  C07K16/26 ,  G01N33/541 ,  G01N33/82

Abstract: The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.

公开(公告)号：US20160356795A1

公开(公告)日：2016-12-08

申请号：US15243187

申请日：2016-08-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N2440/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.

公开(公告)号：US10451639B2

公开(公告)日：2019-10-22

申请号：US15243187

申请日：2016-08-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82 ,  G01N33/00

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.

公开(公告)号：US20150024506A1

公开(公告)日：2015-01-22

申请号：US14501747

申请日：2014-09-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N2440/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.

公开(公告)号：US20140248707A1

公开(公告)日：2014-09-04

申请号：US14277359

申请日：2014-05-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82 ,  C07C401/00

CPC classification number: G01N33/82 ,  C07C401/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

Abstract translation: 用于释放与维生素D结合蛋白结合的维生素D化合物的试剂组合物和用于检测维生素D化合物的体外方法，其中维生素D化合物通过使用该试剂组合物从维生素D结合蛋白中释放出来 以及以这种方式获得的试剂混合物。 还公开了试剂组合物用于释放维生素D化合物以及用于检测维生素D化合物的试剂盒的用途。

公开(公告)号：US20130078729A1

公开(公告)日：2013-03-28

申请号：US13681098

申请日：2012-11-19

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N2440/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.