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1.发明授权Assay for measurement of antibodies binding to a therapeutic monoclonal antibody 有权测定结合治疗性单克隆抗体的抗体的测定公开(公告)号：US09081016B2
公开(公告)日：2015-07-14
申请号：US13766130
申请日：2013-02-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Veit Peter Grunert , Ursula Klause , Pavel Kubalec , Matthias Rothfuss , Barbara Upmeier
CPC classification number: G01N33/6854 , C40B30/04 , G01N2800/52
Abstract: Methods and system for determination of an anti- antibody (anti- AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.
Abstract translation: 在用治疗性单克隆抗体（TmAB）治疗的患者的样品中体外测定抗<治疗性单克隆抗体>抗体（抗-TABAB> AB）的方法和系统。 而且，用于确定特定免疫球蛋白类别的抗原特异性抗体的方法和系统以及用于在用TmAB治疗期间鉴定患有不良药物反应（ADR）的风险的患者的方法和系统。
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2.发明申请ASSAY FOR MEASUREMENT OF ANTIBODIES BINDING TO A THERAPEUTIC MONOCLONAL ANTIBODY 有权抗体结合治疗单克隆抗体的测定方法公开(公告)号：US20130157892A1
公开(公告)日：2013-06-20
申请号：US13766130
申请日：2013-02-13
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： Veit Peter Grunert , Ursula Klause , Pavel Kubalec , Matthias Rothfuss , Barbara Upmeier
IPC: G01N33/68
CPC classification number: G01N33/6854 , C40B30/04 , G01N2800/52
Abstract: Methods and system for determination of an anti- antibody (anti- AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.
Abstract translation: 在用治疗性单克隆抗体（TmAB）治疗的患者的样品中体外测定抗<治疗性单克隆抗体>抗体（抗-TABAB> AB）的方法和系统。 而且，用于确定特定免疫球蛋白类别的抗原特异性抗体的方法和系统以及用于在用TmAB治疗期间鉴定患有不良药物反应（ADR）的风险的患者的方法和系统。
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