公开(公告)号：US20220099690A1

公开(公告)日：2022-03-31

申请号：US17643260

申请日：2021-12-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Friedemann Krause ,  Ruediger Laubender

IPC: G01N35/00 ,  G16H40/40 ,  G16H10/40 ,  G05B23/02

Abstract: A computer-implemented method for determining failures in laboratory equipment comprising: a) receiving a desired probability of false rejection ({hacek over (P)}fr) and a desired error detection rate ({hacek over (E)}D), such as a desired probability of error detection ({hacek over (P)}ed), relating to one or more QC levels (J) of quality control (QC) samples to be processed by the equipment; b) setting a number of runs (R) to one; c) calculating an error detection rate (ÊD) based at least partially on R; d) determining if ÊD is below {hacek over (E)}D, and if so: increase R by one, and repeat steps c) to d), and if not: define a rule for determining failures in the laboratory equipment based, at least partially, on R; e) receiving or collecting standardized QC results; f) applying the rule defined in step d) to the standardized QC results; g) determining failures in the equipment, if the standardized QC results comply with the rule.

公开(公告)号：US20210190736A1

公开(公告)日：2021-06-24

申请号：US17113354

申请日：2020-12-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Albert Geiger ,  Daniel Intelmann ,  Ruediger Laubender ,  Julian Michely ,  Kirill Tarasov

IPC: G01N30/72

Abstract: A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.

公开(公告)号：US20240272177A1

公开(公告)日：2024-08-15

申请号：US18561621

申请日：2022-05-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manuel Dietrich ,  Felix Gruenewald ,  Martin Hund ,  Peter Kastner ,  Martin Klammer ,  Ruediger Laubender ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  G01N33/536 ,  G01N33/58 ,  G16H50/30

CPC classification number: G01N33/6893 ,  G01N33/536 ,  G01N33/58 ,  G01N33/6854 ,  G16H50/30 ,  G01N2333/4703 ,  G01N2800/361 ,  G01N2800/52

Abstract: The present invention relates to methods of assessing whether a patient has adenomyosis or is at risk of developing adenomyosis, to methods of selecting a patient for therapy of adenomyosis, and methods of monitoring a patient suffering from adenomyosis or being treated for adenomyosis, by determining the amount or concentration of sFRP4 in a sample of the patient, and comparing the determined amount or concentration to a reference.

公开(公告)号：US11585791B2

公开(公告)日：2023-02-21

申请号：US17113354

申请日：2020-12-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Albert Geiger ,  Daniel Intelmann ,  Ruediger Laubender ,  Julian Michely ,  Kirill Tarasov

IPC: G01N30/72 ,  G01N30/02 ,  G01N30/40

Abstract: A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.

公开(公告)号：US20250003932A1

公开(公告)日：2025-01-02

申请号：US18294945

申请日：2022-08-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ruediger Laubender ,  Stefan Quint ,  Marius Wagner

IPC: G01N30/86 ,  G01N30/02

Abstract: A computer implemented method (140) for determining lifetime of at least one chromatography column (116) of at least one chromatography device (110), wherein the method (140) comprises the following steps: i) receiving model input chromatography data via at least one communication interface (128); ii) determining at least one state variable indicative of lifetime of the chromatography column (116) using at least one data driven model based on the model input chromatography data using at least one processing device (130); iii) evaluating the determined state variable thereby determining information about lifetime by using the processing device (130), wherein the evaluation comprises comparing the determined state variable to at least one threshold. Further, a test system (112), a computer program and a method for operating a chromatography column (116) are disclosed.

公开(公告)号：US20220155269A1

公开(公告)日：2022-05-19

申请号：US17649801

申请日：2022-02-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Galina Babitzki ,  Ruediger Laubender ,  Julian Michely ,  Andreas Reichert ,  Kirill Tarasov

IPC: G01N30/86 ,  G01N30/72

Abstract: A computer implemented method for automatic peak integration of at least one chromatogram of at least one sample. The method comprises retrieving at least one chromatogram of the chemical related substance and at least one chromatogram of the analyte; evaluating the chromatogram of the chemical related substance, wherein the evaluating comprises determining at least one initial value for analyte retention time by determining retention time of the chemical related substance and adding the retention time of the chemical related substance with a pre-determined or pre-defined constant offset and/or multiplying the retention time of the chemical related substance with a pre-determined or pre-defined constant factor; evaluating the chromatogram of the analyte, wherein the evaluating comprises at least one position determining step; and at least one peak integration step, wherein analyte peak area and analyte peak shape are determined by applying at least one fitting analysis to the chromatogram of the analyte.