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公开(公告)号：US20210239712A1
公开(公告)日：2021-08-05
申请号：US17181390
申请日：2021-02-22
Applicant: Roche Diagnostics Operations, Inc. , Universiteit Maastricht , Academisch Zickenhuis Maastricht
Inventor： Peter Kastner , Andre Ziegler , Ursula-Henrike Wienhues-Thelen , Vinzent Rolny , Manuel Dietrich , Ulrich Schotten
IPC: G01N33/68
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of FGFBP-1 in a sample from the subject, and comparing the amount of FGFBP-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of FGFBP-1.
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公开(公告)号：US20210172962A1
公开(公告)日：2021-06-10
申请号：US17172761
申请日：2021-02-10
Applicant: Roche Diagnostics Operations, Inc. , UNIVERSITEIT MAASTRICHT , AKADEMISCH ZIEKENHUIS MAASTRICHT
Inventor： Manuel Dietrich , Peter Kastner , Vinzent Rolny , Ulrich Schotten , Ursula-Henrike Wienhues-Thelen , Andre Ziegler
IPC: G01N33/68
Abstract: The present invention relates to a method for assessing the risk of stroke in a subject, said method comprising the steps of determining the amount of CES-2 in a sample from the subject, and comparing the amount of CES-2 to a reference amount, whereby the risk of stroke is to be assessed. Moreover, the present invention relates to a method for assessing the efficacy of an anticoagulation therapy and a method for identifying a subject being eligible to the administration of at least one anticoagulation medicament or being eligible for increasing the dosage of at least one anticoagulation medicament.
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公开(公告)号：US20230176077A1
公开(公告)日：2023-06-08
申请号：US17912776
申请日：2021-03-18
Applicant: Universiteit Maastricht , Academisch Ziekenhuis Maastricht , Roche Diagnostics Operations, Inc.
Inventor： Peter Kastner , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , André Ziegler , Manuel Dietrich , Ulrich Schotten
IPC: G01N33/68
CPC classification number: G01N33/6896 , G01N2800/2871 , G01N2800/326 , G01N2800/50 , G01N2333/9121
Abstract: The present invention relates to a method for aiding in the prediction of stroke and/or dementia in a subject, said method comprising a) determining the amount of the biomarker RET (Rearranged during transfection) in a sample from the subject, b) comparing the amount determined in step a) to a reference, and c) aiding in the prediction of stroke and/or dementia. The present invention further relates to a method for aiding in the assessment of the extent of white matter lesions in a subject, a method for aiding in the assessment whether a subject has experienced one or more silent strokes and to a method for aiding in the diagnosis of atrial fibrillation in a subject. Further encompassed by the present invention are the corresponding uses.
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公开(公告)号：US20210156875A1
公开(公告)日：2021-05-27
申请号：US17161998
申请日：2021-01-29
Applicant: Roche Diagnostics Operations, Inc. , Universitaet Maastricht , Academisch Ziekenhuis Maastricht
Inventor： Johann Karl , Peter Kastner , Roberto Latini , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , Andre Ziegler , Manuel Dietrich , Jennifer Meessen , Ulrich Schotten
IPC: G01N33/68
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of DKK3 in a sample from the subject, and comparing the amount of DKK3 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure.
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Patent Agency Ranking
公开(公告)号：US20210215716A1
公开(公告)日：2021-07-15
申请号：US17181386
申请日：2021-02-22
Applicant: Roche Diagnostics Operations, Inc. , Universiteit Maastricht , Academisch Ziekenhuis Maastricht
Inventor： Peter Kastner , Manuel Dietrich , André Ziegler , Ursula-Henrike Wienhues-Thelen , Vinzent Rolny , Ulrich Schotten
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.
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公开(公告)号：US20210190801A1
公开(公告)日：2021-06-24
申请号：US17177673
申请日：2021-02-17
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC. , UNIVERSITEIT MAASTRICHT , ACADEMISCH ZIEKENHUIS MAASTRICT
Inventor： Johann Karl , Peter Kastner , Ursula-Henrike Wienhues-Thelen , Manuel Dietrich , Andre Ziegler , Ulrich Schotten
IPC: G01N33/68 , G01N33/577
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP 10 in a sample from the subject, and comparing the amount of BMP 10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP 10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP 10-type peptide in a sample from a subject.
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公开(公告)号：US20210181211A1
公开(公告)日：2021-06-17
申请号：US17176797
申请日：2021-02-16
Applicant: Roche Diagnostics Operations, Inc. , Universiteit Maastricht , Academisch Zickenhuis Maastricht
Inventor： Peter Kastner , Andre Ziegler , Ursula-Henrike Wienhues-Thelen , Vinzent Rolny , Manuel Dietrich , Ulrich Schotten
IPC: G01N33/68
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of TFPI-2 in a sample from the subject, and comparing the amount of TFPI-2 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for assessing anticoagulation therapy and to methods for predicting the risk of stroke of a subject. Said methods are based on the determination of the amount of TFPI-2 in a sample from the subject.
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公开(公告)号：US20190162737A1
公开(公告)日：2019-05-30
申请号：US16264779
申请日：2019-02-01
Inventor： Johann Karl , Peter Kastner , Roberto Latini , Serge Masson , Ursula-Henrike Wienhues-Thelen , Andre Ziegler , Manuel Dietrich , Ulrich Schotten , Vinzent Rolny
IPC: G01N33/68
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of ESM-1 in a sample from the subject, and comparing the amount of ESM-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure.
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公开(公告)号：US20240272177A1
公开(公告)日：2024-08-15
申请号：US18561621
申请日：2022-05-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Manuel Dietrich , Felix Gruenewald , Martin Hund , Peter Kastner , Martin Klammer , Ruediger Laubender , Heike Wegmeyer , Ursula-Henrike Wienhues-Thelen
IPC: G01N33/68 , G01N33/536 , G01N33/58 , G16H50/30
CPC classification number: G01N33/6893 , G01N33/536 , G01N33/58 , G01N33/6854 , G16H50/30 , G01N2333/4703 , G01N2800/361 , G01N2800/52
Abstract: The present invention relates to methods of assessing whether a patient has adenomyosis or is at risk of developing adenomyosis, to methods of selecting a patient for therapy of adenomyosis, and methods of monitoring a patient suffering from adenomyosis or being treated for adenomyosis, by determining the amount or concentration of sFRP4 in a sample of the patient, and comparing the determined amount or concentration to a reference.
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