公开(公告)号：US11680924B2

公开(公告)日：2023-06-20

申请号：US16829788

申请日：2020-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson ,  Klaus Bauer-Espindola ,  Samuel Evgin ,  Carina Horn ,  Michael Marquant

IPC: G01N27/327

CPC classification number: G01N27/3273

Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

公开(公告)号：US20210349049A1

公开(公告)日：2021-11-11

申请号：US17443260

申请日：2021-07-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US20200292483A9

公开(公告)日：2020-09-17

申请号：US16441282

申请日：2019-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US20200225184A1

公开(公告)日：2020-07-16

申请号：US16829788

申请日：2020-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson ,  Klaus Bauer-Espindola ,  Samuel Evgin ,  Carina Horn ,  Michael Marquant

IPC: G01N27/327

Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

公开(公告)号：US11782009B2

公开(公告)日：2023-10-10

申请号：US17443260

申请日：2021-07-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

CPC classification number: G01N27/3274

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US11125712B2

公开(公告)日：2021-09-21

申请号：US16441282

申请日：2019-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US20190310221A1

公开(公告)日：2019-10-10

申请号：US16441282

申请日：2019-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.