公开(公告)号：US11774395B2

公开(公告)日：2023-10-03

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20180100826A1

公开(公告)日：2018-04-12

申请号：US15830672

申请日：2017-12-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant

IPC: G01N27/30 ,  G01N27/327 ,  C12Q1/00 ,  C12Q1/54

CPC classification number: G01N27/301 ,  C12Q1/006 ,  C12Q1/54 ,  G01N27/3272

Abstract: A method and test element for electrochemically detecting at least one analyte in a sample are provided, wherein the method comprises: a) providing at least one test element comprising at least one first electrode contacting a test chemistry and at least one second electrode, wherein a surface of the second electrode consists of silver metal; b) contacting both the first and second electrodes with the sample comprising chloride ions; c) applying a first voltage between the first electrode as a cathode and the second electrode as an anode with a voltage sufficient for forming a layer of silver chloride at the surface of the second electrode; d) applying a second voltage between the first electrode as the anode and the second electrode as the cathode; and e) determining an electrical signal between the first and the second electrodes, whereby the analyte in the sample comprising the chloride ions is detected.

公开(公告)号：US20160091482A1

公开(公告)日：2016-03-31

申请号：US14963576

申请日：2015-12-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Carina Horn ,  Michael Marquant ,  Christine Nortmeyer ,  Volker Unkrig

IPC: G01N33/49 ,  G01N21/78 ,  G01N27/12 ,  G01N21/64

CPC classification number: G01N33/492 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N27/02 ,  G01N27/12 ,  G01N27/3274 ,  G01N2021/7786

Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

Abstract translation: 公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。 测试化学品是适于执行至少一个检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。 产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。 执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。

公开(公告)号：US20210349049A1

公开(公告)日：2021-11-11

申请号：US17443260

申请日：2021-07-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US20210080420A1

公开(公告)日：2021-03-18

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20200292483A9

公开(公告)日：2020-09-17

申请号：US16441282

申请日：2019-06-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Samuel Evgin ,  Melanie Klein

IPC: G01N27/327

Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

公开(公告)号：US20200225184A1

公开(公告)日：2020-07-16

申请号：US16829788

申请日：2020-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson ,  Klaus Bauer-Espindola ,  Samuel Evgin ,  Carina Horn ,  Michael Marquant

IPC: G01N27/327

Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

公开(公告)号：US20190079045A1

公开(公告)日：2019-03-14

申请号：US16185210

申请日：2018-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Goebbert ,  Eloisa Lopez-Calle ,  Michael Marquant ,  Christine Nortmeyer ,  Katja Reiter ,  Reiner Stein

IPC: G01N27/327 ,  G01N21/78 ,  B01L3/00

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.

公开(公告)号：US11215577B2

公开(公告)日：2022-01-04

申请号：US16185210

申请日：2018-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Goebbert ,  Eloísa Lopez-Calle ,  Michael Marquant ,  Christine Nortmeyer ,  Katja Reiter ,  Reiner Stein

IPC: G01N27/327 ,  B01L3/00 ,  G01N21/78

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.

公开(公告)号：US10590458B2

公开(公告)日：2020-03-17

申请号：US15442202

申请日：2017-02-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Marquant ,  Michael Reinhardt

IPC: G01N27/327 ,  C12Q1/00 ,  G01N33/487 ,  G01N33/49

Abstract: A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.