公开(公告)号：US20180348140A1

公开(公告)日：2018-12-06

申请号：US16044897

申请日：2018-07-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Klaus Bauer-Espindola

IPC: G01N21/66 ,  G01N35/00 ,  G01N35/10 ,  G01N27/416 ,  G01N27/327

CPC classification number: C12Q1/00 ,  G01N33/5438 ,  G01N33/582

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.

公开(公告)号：US20200225184A1

公开(公告)日：2020-07-16

申请号：US16829788

申请日：2020-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson ,  Klaus Bauer-Espindola ,  Samuel Evgin ,  Carina Horn ,  Michael Marquant

IPC: G01N27/327

Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

公开(公告)号：US11680924B2

公开(公告)日：2023-06-20

申请号：US16829788

申请日：2020-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Lambertson ,  Klaus Bauer-Espindola ,  Samuel Evgin ,  Carina Horn ,  Michael Marquant

IPC: G01N27/327

CPC classification number: G01N27/3273

Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.

公开(公告)号：US11796477B2

公开(公告)日：2023-10-24

申请号：US16044897

申请日：2018-07-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Klaus Bauer-Espindola

IPC: G01N21/66 ,  G01N35/00 ,  G01N27/327 ,  G01N27/416 ,  G01N35/10

CPC classification number: G01N21/66 ,  G01N27/3277 ,  G01N27/4163 ,  G01N35/00623 ,  G01N35/00722 ,  G01N35/1004 ,  G01N2035/00891

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving

a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode,
b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode,
c. comparing the result of the first EIS and the second EIS,

providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.