利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.029 秒)

    Medical use for tachykinin antagonists
    3.
    发明授权
    Medical use for tachykinin antagonists 失效
    速激肽拮抗剂的医疗用途

    公开(公告)号：US5538982A

    公开(公告)日：1996-07-23

    申请号：US269079

    申请日：1994-06-30

    申请人： Russell M. Hagan ,  Keith T. Bunce

    发明人： Russell M. Hagan ,  Keith T. Bunce

    IPC分类号： A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/57 ,  A61K38/00 ,  A61K45/06 ,  A61P1/08 ,  A61P25/24 ,  A61P43/00 ,  C07D453/02 ,  C07D487/08 ,  A61K31/20 ,  A61K31/55 ,  A61K31/135

    CPC分类号： C07D487/08 ,  A61K31/44 ,  A61K31/445 ,  A61K31/57 ,  A61K45/06 ,  Y10S514/872

    摘要： The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups;R.sup.2 and R.sup.3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl and cyano groups;n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.

    摘要翻译： 本发明涉及速激肽拮抗剂（包括P物质拮抗剂和其他神经激肽拮抗剂）在治疗呕吐中的用途。 还描述了式（I）的新型速激肽拮抗剂，其制备方法，含有它们的药物组合物及其医疗用途。 （I）其中R表示环A或2-吡啶基或2-吡啶基-N-氧化物; R 1选自卤素原子和C 1-4烷基，C 1-4烷氧基，三氟甲基和S（O）n C 1-4烷基; R 2和R 3可以相同或不同，各自独立地选自氢和卤素原子和C 1-4烷基，C 1-4烷氧基，三氟甲基和氰基; n表示0，1或2; 及其药学上可接受的盐和溶剂化物。

    Hermetic compressor discharge line thermal block
    4.
    发明授权
    Hermetic compressor discharge line thermal block 失效
    密封压缩机排放管路热块

    公开(公告)号：US4506519A

    公开(公告)日：1985-03-26

    申请号：US526108

    申请日：1983-08-24

    申请人： Robert L. Morse ,  Russell M. Hagan

    发明人： Robert L. Morse ,  Russell M. Hagan

    IPC分类号： F25B43/00 ,  F25B1/00

    CPC分类号： F25B43/00

    摘要： A hermetic compressor discharge line thermal block is hermetically coupled in the discharge line between a condenser and compressor adjacent to the discharge outlet of the compressor. The device is formed to define a well for removably receiving a heating element, and has a hermetically sealed chamber substantially surrounding the heater well and electric heating element. Upon compressor shutdown, liquid refrigerant migrating from the condenser partially fills the chamber, thereby decreasing the temperature of the heating element below a predetermined temperature, thereby causing the heating element to become electrically conductive to supply heat to the chamber to evaporate the liquid refrigerant therein and to prevent further accumulation of liquid. If a positive temperature coefficient heater is used, after thermal stabilization and during compressor operation, the heat generated either by the compressor or by the heating element itself raises the temperature of the element, thereby causing the heating element to become substantially less electrically conductive to reduce the supply of heat to the chamber. The discharge line thermal block device prevents the migration of liquid refrigerant from the condenser to the compressor to thereby prevent slugging during compressor start-up.

    摘要翻译： 封闭式压缩机排出管线热块气密地联接在冷凝器和与压缩机的排出口相邻的压缩机之间的排放管线中。 该装置形成为限定用于可移除地接收加热元件的阱，并且具有基本上围绕加热器井和电加热元件的气密密封室。 在压缩机关闭时，从冷凝器迁移的液体制冷剂部分地填充室，从而将加热元件的温度降低到预定温度以下，从而使加热元件变得导电，从而向室内供应热量以使其中的液态制冷剂蒸发， 以防止液体进一步积聚。 如果使用正温度系数加热器，在热稳定化之后和在压缩机运行期间，由压缩机或加热元件本身产生的热量会升高元件的温度，从而使加热元件变得基本上更小的导电性以减少 向室供应热量。 排放管道热阻装置防止液体制冷剂从冷凝器迁移到压缩机，从而防止在压缩机启动期间发生堵塞。