公开(公告)号：US20220127228A1

公开(公告)日：2022-04-28

申请号：US17296542

申请日：2020-07-21

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing WAN ,  Pengcheng LIAN ,  Wenhao LONG ,  Jingjing LI ,  Yonggao ZHENG

IPC: C07D209/48 ,  C07C303/40 ,  C07C67/287 ,  C07C201/12 ,  C07C253/30 ,  C07C315/04 ,  C07B39/00

Abstract: The invention provides a method for producing a dichloro addition product of an aliphatic olefin by photocatalysis under visible light. The method includes reacting an aliphatic olefin as a substrate with hydrochloric acid as a chlorine source in an organic solvent under visible light irradiation in the presence of copper chloride with visible light absorption ability as a catalyst, to obtain the dichloro addition product of the aliphatic olefin, wherein the reaction is carried out under an oxygen-containing atmosphere, the aliphatic olefin comprises a carbon-carbon double bond and a C9-C15 aliphatic chain connected to the carbon-carbon double bond by a covalent bond. In the invention, visible light is used to provide the energy and a transition metal chloride with visible light absorption ability is used to undergo light-induced electron transfer from chloride with a reaction substrate, thereby initiating an addition reaction to obtain a dichloro addition product.

公开(公告)号：US20240270675A1

公开(公告)日：2024-08-15

申请号：US18037550

申请日：2021-02-07

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing WAN ,  Yonggao ZHENG ,  Suyan TAO ,  Xingxing LI ,  Xionglue CHENG

IPC: C07C67/08

CPC classification number: C07C67/08 ,  C07C2531/02

Abstract: The present invention relates to a method for preparing a carboxylic acid ester compound. Under the catalysis of nitrite, a carboxylic acid reacts with an alcohol in air so as to obtain an ester compound; and the alcohol is ethanol, propanol or trifluoroethanol. The present invention has the advantages such as mild reaction conditions, rich source of raw materials, wide universality of reaction substrates, and simple operation, and can modify a series of carboxylic acids having medicinal properties and aliphatic carboxylic acids such as biologically active amino acids.

公开(公告)号：US20230054928A1

公开(公告)日：2023-02-23

申请号：US17780699

申请日：2020-11-27

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing WAN ,  Hanghang WANG ,  Yonggao ZHENG ,  Pengcheng LIAN ,  Jingjing LI

IPC: C07C315/02 ,  C07C315/06

Abstract: Disclosed is a method for preparing β-carbonyl sulfones. The method comprises: by taking an α-carbonyl diazo compound and sodium arylsulfinate as reaction substrates, cheap silver nitrate as an optimal catalyst, 1,10-phenanthroline as a ligand, and potassium persulfate as an oxidant, carrying out coupling reaction in a mixed solvent of acetonitrile and water to obtain a β-carbonyl sulfones compound. Compared with the prior art, the method has the following advantages: a wide range of reaction substrates, short reaction time, a relatively high reaction yield, a mild reaction condition, etc. In the present invention, non-toxic and harmless reagents are used as reaction raw materials, so that it has no harm to the environment and satisfies the requirements of contemporary green chemistry development. Post-reaction treatment is relatively simple, and is convenient for separation and purification. In addition, the reaction can achieve gram-scale synthesis, and lays a foundation for actual applications.

公开(公告)号：US20210221769A1

公开(公告)日：2021-07-22

申请号：US17205937

申请日：2021-03-18

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing WAN ,  Hanghang WANG

IPC: C07C313/04

Abstract: The present invention discloses a method for preparing a perfluoroalkyl sulfinate ester. The method includes reacting an α-carbonyldiazo compound and a sodium perfluoroalkyl sulfinate, in an organic solvent, in the presence of anhydrous copper acetate as an optimal catalyst and tert-butyl hydroperoxide (TBHP) as a green oxidant, to obtain the perfluoroalkyl sulfinate ester. Compared to the prior art, the present method has the advantages of a wide range of reaction substrates, a short reaction time, a high reaction yield, and mild reaction conditions. The reaction does not require pre-activation of sodium perfluoroalkyl sulfinate, which can participate in the reaction directly, making reaction operations simple. The present method uses TBHP as a green oxidant and produces tert-butanol and water after reaction. Moreover, the present method avoids using a bromide or a chloride as a reaction material, and thus avoids formation of a large amount of a halide salt.

公开(公告)号：US20210024472A1

公开(公告)日：2021-01-28

申请号：US17067721

申请日：2020-10-11

Applicant: SOOCHOW UNIVERSITY

Inventor： Haiyan LI ,  Huihuang LI ,  Yaxiong WANG ,  Xiaobing WAN

IPC: C07D249/10 ,  B01J23/72

Abstract: A method for preparing 1,2,4-triazole includes using a fluoroborate aryl diazonium salt, a diazoester derivative and an organic nitrile as reaction substrates, a transition metal salt as a catalyst, and an inorganic base as an additive in a cyclization reaction. The method has the following characteristics: the reaction is economical; the substrate is universal; the post-functionalization is easy; the reaction conditions are mild; the reaction can be performed in air; the catalyst amount used is less; and the post-treatment is simple. Meanwhile, the raw materials, such as the reactants and the catalyst used, are inexpensive and easily available; the reaction composition is reasonable; no ligand is needed; there are less reaction steps; and only one step of reaction is required to obtain a high yield, meeting the requirements and directions of contemporary green chemistry and medicinal chemistry, being suitable for screening highly active 1,2,4-triazole drugs.