公开(公告)号：US10039771B2

公开(公告)日：2018-08-07

申请号：US15131358

申请日：2016-04-18

Applicant: STC.UNM

Inventor： Alexandre Chigaev ,  Larry A. Sklar ,  Dominique Perez

IPC: A61K35/12 ,  A61K31/58 ,  A61K31/47 ,  A61K31/122 ,  G01N33/50 ,  A61K31/4425 ,  A61K31/357 ,  A61K31/343 ,  A61K31/35 ,  A61K31/437 ,  A61K31/00 ,  A61K31/365 ,  A61K45/06

Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.

公开(公告)号：US20140088034A1

公开(公告)日：2014-03-27

申请号：US14115170

申请日：2012-05-10

Applicant: STC.UNM

Inventor： Alexandre Chigaev ,  Larry A. Sklar

IPC: A61K31/708 ,  A61K31/132

CPC classification number: A61K31/708 ,  A61K31/132 ,  A61K31/506 ,  A61K31/655 ,  A61K31/665 ,  A61K45/06 ,  G01N33/5008 ,  G01N33/57488 ,  G01N2500/10 ,  G01N2800/50

Abstract: The invention provides methods of treating nitric oxide/cGMP pathway-cell adhesion disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention relates to a method for down-regulating α4β1-integrin affinity and inhibiting and reversing adhesion formation in patients or subjects in need using a nitric oxide donor.

Abstract translation: 本发明提供了治疗一氧化氮/ cGMP途径 - 细胞粘附病症和相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明涉及一种下调α4和bgr1整合素亲和力并抑制和逆转使用一氧化氮供体的患者或需要受试者的粘连形成的方法。

公开(公告)号：US20160228457A1

公开(公告)日：2016-08-11

申请号：US15131358

申请日：2016-04-18

Applicant: STC.UNM

Inventor： Alexandre Chigaev ,  Larry A. Sklar ,  Dominique Perez

IPC: A61K31/58 ,  A61K31/47 ,  A61K31/357 ,  A61K45/06 ,  A61K31/365

CPC classification number: A61K31/58 ,  A61K31/00 ,  A61K31/122 ,  A61K31/343 ,  A61K31/35 ,  A61K31/357 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4425 ,  A61K31/47 ,  A61K45/06 ,  G01N33/5011 ,  G01N2500/10 ,  G01N2800/52

Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.

Abstract translation: 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的cAMP外排抑制剂来抑制患有或有风险发展为癌症的受试者的cAMP外排和增加细胞内cAMP的方法。 还提供了新颖的化合物，药物组合物，诊断和筛选方法。