公开(公告)号：US10039771B2

公开(公告)日：2018-08-07

申请号：US15131358

申请日：2016-04-18

Applicant: STC.UNM

Inventor： Alexandre Chigaev ,  Larry A. Sklar ,  Dominique Perez

IPC: A61K35/12 ,  A61K31/58 ,  A61K31/47 ,  A61K31/122 ,  G01N33/50 ,  A61K31/4425 ,  A61K31/357 ,  A61K31/343 ,  A61K31/35 ,  A61K31/437 ,  A61K31/00 ,  A61K31/365 ,  A61K45/06

Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.

公开(公告)号：US20160228457A1

公开(公告)日：2016-08-11

申请号：US15131358

申请日：2016-04-18

Applicant: STC.UNM

Inventor： Alexandre Chigaev ,  Larry A. Sklar ,  Dominique Perez

IPC: A61K31/58 ,  A61K31/47 ,  A61K31/357 ,  A61K45/06 ,  A61K31/365

CPC classification number: A61K31/58 ,  A61K31/00 ,  A61K31/122 ,  A61K31/343 ,  A61K31/35 ,  A61K31/357 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4425 ,  A61K31/47 ,  A61K45/06 ,  G01N33/5011 ,  G01N2500/10 ,  G01N2800/52

Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.

Abstract translation: 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的cAMP外排抑制剂来抑制患有或有风险发展为癌症的受试者的cAMP外排和增加细胞内cAMP的方法。 还提供了新颖的化合物，药物组合物，诊断和筛选方法。