公开(公告)号：US20190060289A1

公开(公告)日：2019-02-28

申请号：US16101762

申请日：2018-08-13

Applicant: STC.UNM

Inventor： Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A Sklar

IPC: A61K31/436 ,  A61K31/54 ,  A61K31/12 ,  A61K31/136 ,  A61K31/585 ,  A61K31/472 ,  A61K31/473 ,  A61K31/4535 ,  A61K31/546 ,  A61K31/4365 ,  A61K31/519 ,  A61K31/5685 ,  A61K31/517 ,  A61K31/522 ,  A61K31/4184 ,  G01N33/68 ,  C07K16/18 ,  G01N33/569 ,  A61K31/65

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

公开(公告)号：US20170112813A1

公开(公告)日：2017-04-27

申请号：US15287323

申请日：2016-10-06

Applicant: STC.UNM

Inventor： Vojo Deretic ,  Eliseo Castillo ,  Steven Bradfute ,  Larry A. Sklar

IPC: A61K31/436 ,  A61K31/136 ,  A61K31/12 ,  A61K31/4184

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.