公开(公告)号：US10010558B2

公开(公告)日：2018-07-03

申请号：US15552541

申请日：2016-02-23

Applicant: STC.UNM ,  Charles Melancon ,  Pamela Hall ,  Jacob Greenberg ,  Yasushi Ogasawara ,  Snezna Rogelj

Inventor： Charles Melancon ,  Pamela Hall ,  Jacob Greenberg ,  Yasushi Ogasawara ,  Snezna Rogelj

IPC: A61K31/65

CPC classification number: A61K31/65 ,  A61K31/122 ,  A61K31/192

Abstract: In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating a subject having, or at risk of having, a condition caused by a microbial infection treatable with frankiamicin A. Generally, the method includes administering to the subject an amount of frankiamicin A effective to ameliorate at least one symptom or clinical sign of the condition.

公开(公告)号：US20190038735A1

公开(公告)日：2019-02-07

申请号：US16074886

申请日：2017-02-01

Applicant: STC.UNM

Inventor： Pamela Hall ,  Bryce Chackerian ,  David S. Peabody ,  Seth Michael Daly ,  Bradley Owen Elmore ,  Kathleen Triplett

IPC: A61K39/085 ,  A61P31/04 ,  A61P37/04

CPC classification number: A61K39/085 ,  A61K2039/52 ,  A61K2039/5258 ,  A61P31/04 ,  A61P37/04 ,  C12N2795/18123

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

公开(公告)号：US10561648B2

公开(公告)日：2020-02-18

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61K35/644 ,  A61K38/14 ,  C07K14/705 ,  A61K31/4741 ,  A61P31/04

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition —and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US20190000830A1

公开(公告)日：2019-01-03

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K31/473 ,  A61K31/4741 ,  A61K35/644 ,  A61K38/14 ,  A61K45/06 ,  A61P31/04 ,  C07K14/70567 ,  A61K2300/00

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition—and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US10821167B2

公开(公告)日：2020-11-03

申请号：US16074886

申请日：2017-02-01

Applicant: STC.UNM

Inventor： Pamela Hall ,  Bryce Chackerian ,  David S. Peabody ,  Seth Michael Daly ,  Bradley Owen Elmore ,  Kathleen Triplett

IPC: C12Q1/68 ,  A61K39/085 ,  A61P37/04 ,  A61P31/04 ,  A61K39/00

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.