公开(公告)号：US20170355951A1

公开(公告)日：2017-12-14

申请号：US15621875

申请日：2017-06-13

申请人： Sanaria Inc. ,  Johns Hopkins University

发明人： Russell H. TAYLOR ,  Amanda CANEZIN ,  Mariah SCHRAM ,  lulian IORDACHITA ,  Gregory CHIRIKJIAN ,  Michelle LASKOWSKI ,  Sumana CHAKRAVARTY ,  Stephen HOFFMAN

IPC分类号： C12N3/00 ,  C12N1/10 ,  C12M1/00

CPC分类号： C12N3/00 ,  C12M47/04 ,  C12N1/10

摘要： A device and method of use for augmenting the extraction of salivary glands from Plasmodium-infected mosquitoes, where the sporozoite stage of Plasmodium primarily resides. Sporozoites are useful for research as well as for the immunogen in whole parasite vaccines for the prevention of malaria. The device and methods of use disclosed herein greatly increase the rate at which sporozoites can be harvested.

公开(公告)号：US20210045375A1

公开(公告)日：2021-02-18

申请号：US16995164

申请日：2020-08-17

申请人： Sanaria Inc. ,  Johns Hopkins University

发明人： Russell H. TAYLOR ,  Gregory CHIRIKJIAN ,  Iulian IORDACHITA ,  Henry PHALEN ,  Hongtao WU ,  Mengdi XU ,  Shengnan LU ,  Michael Aaron POZIN ,  Jin Seob KIM ,  Can KOCABALKANLI ,  Balazs VAGVOLGYI ,  Brian K. CHIRIKJIAN ,  Joshua DAVIS ,  Ting DA ,  John S. CHIRIKJIAN ,  Sumana CHAKRAVARTY ,  Stephen HOFFMAN

IPC分类号： A01M1/02

摘要： Systems and methods for providing a combined mosquito staging and dissection system are disclosed. The system can include a mosquito staging subsystem; a robotic pick-and-place station; and a dissection, extrusion, collection, and disposal subsystem. The subsystems can include one or more stations to provide orientation, decapitation, extrusion of salivary glands, and disposal of carcasses of the mosquitoes. The resident live sporozoites from the salivary glands can be used to produce Plasmodium SPZ-based vaccines.

公开(公告)号：US20140120138A1

公开(公告)日：2014-05-01

申请号：US14065012

申请日：2013-10-28

申请人： The Rockefeller University ,  Sanaria, Inc.

发明人： Sumana CHAKRAVARTY ,  Stephen L. Hoffman ,  Moriya Tsuji

IPC分类号： A61K39/015 ,  A61K9/00 ,  A61K39/39

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0021 ,  A61K39/015 ,  A61K2039/522 ,  A61K2039/54 ,  A61K2039/55511 ,  Y02A50/412

摘要： Disclosed herein are pharmaceutical compositions comprising Plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range Plasmodium and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.

摘要翻译： 本文公开了包含用于预防或降低疟疾风险的疫苗中的疟原虫子孢子阶段寄生虫和相容性糖脂佐剂的药物组合物。 特别地，人宿主范围用于天然杀伤T（NKT）细胞的配体的α-半乳糖神经酰胺（α-GalCer）的疟原虫和类似物在药物组合物中组合，其可用作抗疟疾疫苗。 还提供了使用方法。

公开(公告)号：US20160158351A1

公开(公告)日：2016-06-09

申请号：US15046575

申请日：2016-02-18

申请人： Sanaria Inc. ,  The Rockefeller University

发明人： Sumana CHAKRAVARTY ,  Stephen L. HOFFMAN ,  Moriya TSUJI

IPC分类号： A61K39/39 ,  A61K9/00 ,  A61K39/015

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0021 ,  A61K39/015 ,  A61K2039/522 ,  A61K2039/54 ,  A61K2039/55511 ,  Y02A50/412

摘要： Disclosed herein are pharmaceutical compositions comprising Plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range Plasmodium and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.

摘要翻译： 本文公开了包含用于预防或降低疟疾风险的疫苗中的疟原虫子孢子阶段寄生虫和相容性糖脂佐剂的药物组合物。 特别地，人宿主范围用于天然杀伤T（NKT）细胞的配体的α-半乳糖神经酰胺（α-GalCer）的疟原虫和类似物在药物组合物中组合，其可用作抗疟疾疫苗。 还提供了使用方法。