公开(公告)号：US20140329914A1

公开(公告)日：2014-11-06

申请号：US14239954

申请日：2012-08-31

申请人： Satoru Kobayashi ,  Satoshi Okada ,  Kentaro Takamura

发明人： Satoru Kobayashi ,  Satoshi Okada ,  Kentaro Takamura

IPC分类号： A61K47/42 ,  A61K31/397

CPC分类号： A61K47/42 ,  A61K31/397 ,  A61K38/10

摘要： Provided are compounds and methods useful for sealing air leaks in the thoracic cavity. Compounds and compositions of the invention comprise certain amphiphilic peptides, 8-200 amino acid residues long, that self-assemble spontaneously to form a gel in the presence of physiological pH and/or in the presence of a cation. In one embodiment, the peptide comprises a repeated sequence arginine-alanine-aspartic acid-alanine (RADA). Methods of the invention include a method of occluding a pulmonary air leak in a subject, comprising applying a compound of the invention to the site of a pulmonary air leak. The compounds and methods of the invention can be combined with other agents useful to treat cancer, inflammation, or infection.

摘要翻译： 提供了用于密封胸腔漏气的化合物和方法。 本发明的化合物和组合物包含长达8-200个氨基酸残基的某些两亲肽，其在生理pH和/或阳离子存在下自发组装以形成凝胶。 在一个实施方案中，肽包含重复序列精氨酸 - 丙氨酸 - 天冬氨酸 - 丙氨酸（RADA）。 本发明的方法包括阻塞受试者的肺部空气泄漏的方法，包括将本发明的化合物施用于肺部空气泄漏的部位。 本发明的化合物和方法可以与可用于治疗癌症，炎症或感染的其它试剂组合。

公开(公告)号：US20110201541A1

公开(公告)日：2011-08-18

申请号：US13122758

申请日：2009-10-06

申请人： Kentaro Takamura ,  Satoshi Gojo ,  Satoru Kobayashi

发明人： Kentaro Takamura ,  Satoshi Gojo ,  Satoru Kobayashi

IPC分类号： A61K38/00 ,  C07K7/08

CPC分类号： A61K38/10 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/08 ,  A61K38/16 ,  A61L31/047 ,  A61L31/148 ,  A61L2400/04 ,  A61L2430/36 ,  C07K7/06 ,  C07K7/08

摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

摘要翻译： 提供了可应用于包括人在内的大型哺乳动物的生物可吸收肽组织封闭剂，通过人工合成获得的肽组织封闭剂，以避免病毒感染等。 组织封闭剂含有肽，其中肽是具有8-200个氨基酸残基的亲水性肽，亲水氨基酸和疏水性氨基酸交替键合，并且是在水溶液中显示“结构”的自组装肽 在生理pH和/或阳离子存在下。

公开(公告)号：US10576123B2

公开(公告)日：2020-03-03

申请号：US13122758

申请日：2009-10-06

申请人： Kentaro Takamura ,  Satoshi Gojo ,  Satoru Kobayashi

发明人： Kentaro Takamura ,  Satoshi Gojo ,  Satoru Kobayashi

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K38/16 ,  A61L31/14 ,  A61L31/04 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/08 ,  C07K7/06

摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

公开(公告)号：US20110002880A1

公开(公告)日：2011-01-06

申请号：US12746520

申请日：2008-12-04

申请人： Kentaro Takamura ,  Jiro Takei

发明人： Kentaro Takamura ,  Jiro Takei

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K38/47 ,  A61K33/18 ,  A61K38/18 ,  A61K38/28 ,  A61K38/20 ,  A61K38/48 ,  A61P17/02 ,  A61P17/00 ,  A61K35/14

CPC分类号： A61K38/10 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/45

摘要： The invention relates to a material for wound healing and skin reconstruction containing a peptide, wherein the peptide is a self-assembling peptide which is an amphiphilic peptide having 8 to 200 amino acid residues with periodic repeats of alternating hydrophilic amino acids and hydrophobic amino acids, and forms a stable β-sheet structure in an aqueous solution in the presence of a monovalent ion. The material for wound healing and skin reconstruction of the present invention is capable of healing a wound area of mammals quicker than spontaneous recovery without leaving any scars, wherein the material has no potential risk of infectious disease such as virus transmission.

摘要翻译： 本发明涉及包含肽的伤口愈合和皮肤重建材料，其中肽是自组装肽，其是具有8至200个氨基酸残基并具有交替的亲水氨基酸和疏水性氨基酸的周期性重复的两亲肽， 并在一价离子的存在下在水溶液中形成稳定的bgr-sheet结构。 用于本发明的伤口愈合和皮肤重建的材料能够比自发恢复更快地愈合哺乳动物的伤口区域，而不会留下任何疤痕，其中该材料不具有感染性疾病如病毒传播的潜在风险。