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![NOVEL PHARMACEUTICAL USE OF THIOPHENE [3,2-D] PYRIMIDINE-4-KETONE COMPOUND](/abs-image/US/2021/01/21/US20210015824A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210015824A1
公开(公告)日：2021-01-21
申请号：US16978563
申请日：2019-03-08
发明人： Hong LIU , Jia LI , Jiang WANG , Yi ZANG , Jian LI , Jingya LI , Dandan SUN , Hualiang JIANG , Kaixian CHEN
IPC分类号： A61K31/5377 , A61K31/519 , A61P1/16
摘要： Disclosed is use of a thieno[3,2-d]pyrimidin-4-one compound represented by general formula (I). Definition of each substituent is as stated in the description and claims, and the compound is used for preparing medicines for treating and/or preventing liver fibrosis and related diseases or preparing a DPP-4 inhibitor, or is used as a DPP-4 inhibitor.
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公开(公告)号：US20220213083A1
公开(公告)日：2022-07-07
申请号：US17603823
申请日：2020-04-20
发明人： Huaqiang XU , Jia LI , Jingjing SHI , Yi ZANG , Dandan SUN , Mingliang LIU , Rongrong XIE , Erli YOU , Lixin GAO , Qian TAN
IPC分类号： C07D413/14 , C07D487/08 , A61P1/16
摘要： An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.
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公开(公告)号：US20230357244A1
公开(公告)日：2023-11-09
申请号：US18029359
申请日：2021-09-28
发明人： Huaqiang XU , Jia LI , Jingjing SHI , Yi ZANG , Dandan SUN , Mingliang LIU , Rongrong XIE , Erli YOU , Lixin GAO , Qian TAN
IPC分类号： C07D471/08
CPC分类号： C07D471/08
摘要： A strong FXR small-molecule agonist, and a preparation method therefor and use thereof, the structure of the agonist being represented by formula (I), are provided. In the formula, each substituent is as defined in the description and the claims. The compound provided has the advantages of high FXR agonist activity, simple synthesis, easily available raw materials and the like, and can be used for preparing medicines for treating FXR related diseases.
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