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公开(公告)号:US20210015824A1
公开(公告)日:2021-01-21
申请号:US16978563
申请日:2019-03-08
发明人: Hong LIU , Jia LI , Jiang WANG , Yi ZANG , Jian LI , Jingya LI , Dandan SUN , Hualiang JIANG , Kaixian CHEN
IPC分类号: A61K31/5377 , A61K31/519 , A61P1/16
摘要: Disclosed is use of a thieno[3,2-d]pyrimidin-4-one compound represented by general formula (I). Definition of each substituent is as stated in the description and claims, and the compound is used for preparing medicines for treating and/or preventing liver fibrosis and related diseases or preparing a DPP-4 inhibitor, or is used as a DPP-4 inhibitor.
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公开(公告)号:US20220213083A1
公开(公告)日:2022-07-07
申请号:US17603823
申请日:2020-04-20
发明人: Huaqiang XU , Jia LI , Jingjing SHI , Yi ZANG , Dandan SUN , Mingliang LIU , Rongrong XIE , Erli YOU , Lixin GAO , Qian TAN
IPC分类号: C07D413/14 , C07D487/08 , A61P1/16
摘要: An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.
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