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公开(公告)号：US20120239106A1
公开(公告)日：2012-09-20
申请号：US13404814
申请日：2012-02-24
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译： 可以向His束提供刺激能量以激活自然心脏收缩机制。 间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。 例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。
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公开(公告)号：US08761880B2
公开(公告)日：2014-06-24
申请号：US13404814
申请日：2012-02-24
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译： 可以向His束提供刺激能量以激活自然心脏收缩机制。 间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。 例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。
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3.发明申请METHOD AND APPARATUS FOR IDENTIFICATION OF ISCHEMIC/INFARCTED REGIONS AND THERAPY OPTIMIZATION 有权用于鉴别化学/感染性地区和治疗优化的方法和装置公开(公告)号：US20120277607A1
公开(公告)日：2012-11-01
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激 。
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4.发明授权Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权用于鉴别缺血/梗死区域的方法和装置以及治疗优化公开(公告)号：US08219210B2
公开(公告)日：2012-07-10
申请号：US11541837
申请日：2006-10-02
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑的刺激 。
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公开(公告)号：US20120101542A1
公开(公告)日：2012-04-26
申请号：US13277617
申请日：2011-10-20
IPC分类号： A61N1/365
摘要： An A-H delay can be specified, such as by computing the A-H delay using a measured cardiovascular physiologic parameter. The A-H delay can be used for specifying timing between a paced or sensed atrial contraction and a His-bundle pacing time.
摘要翻译： 可以指定A-H延迟，例如通过使用测量的心血管生理参数计算A-H延迟。 A-H延迟可用于指定节奏或感觉到的心房收缩与His束起搏时间之间的时间。
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公开(公告)号：US08954147B2
公开(公告)日：2015-02-10
申请号：US13277617
申请日：2011-10-20
摘要： An A-H delay can be specified, such as by computing the A-H delay using a measured cardiovascular physiologic parameter. The A-H delay can be used for specifying timing between a paced or sensed atrial contraction and a His-bundle pacing time.
摘要翻译： 可以指定A-H延迟，例如通过使用测量的心血管生理参数计算A-H延迟。 A-H延迟可用于指定节奏或感觉到的心房收缩与His束起搏时间之间的时间。
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7.发明授权Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权用于鉴别缺血/梗死区域的方法和装置以及治疗优化公开(公告)号：US08489204B2
公开(公告)日：2013-07-16
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激 。
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8.发明申请Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权用于鉴别缺血/梗死区域的方法和装置以及治疗优化公开(公告)号：US20080082135A1
公开(公告)日：2008-04-03
申请号：US11541837
申请日：2006-10-02
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激 。
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公开(公告)号：US08600499B2
公开(公告)日：2013-12-03
申请号：US11566896
申请日：2006-12-05
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61F2/82 , A61N1/3688
摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
摘要翻译： 一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。 可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。 该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。
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10.发明授权Automatic adaptation of A-V delay and HR for heart failure using beat to beat measures 有权自动适应心律失常的A-V延迟和人力资源公开(公告)号：US08463380B2
公开(公告)日：2013-06-11
申请号：US13357259
申请日：2012-01-24
申请人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
发明人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译： 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。
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