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公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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公开(公告)号：US20130096451A1
公开(公告)日：2013-04-18
申请号：US13708196
申请日：2012-12-07
IPC分类号： A61B7/00
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
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公开(公告)号：US08332034B2
公开(公告)日：2012-12-11
申请号：US12964902
申请日：2010-12-10
IPC分类号： A61N1/365
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。
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公开(公告)号：US08317717B2
公开(公告)日：2012-11-27
申请号：US12283760
申请日：2008-09-16
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译： 心律管理系统包括提供检测第三心音的心音检测器（S3）。 诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。 心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。 然后从S3检测窗口内的声信号检测S3的出现。
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5.发明授权公开(公告)号：US08277389B2
公开(公告)日：2012-10-02
申请号：US13178945
申请日：2011-07-08
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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公开(公告)号：US20120232607A1
公开(公告)日：2012-09-13
申请号：US13479979
申请日：2012-05-24
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译： 响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。 使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。 将估计值与阈值进行比较。 该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。 响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。
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公开(公告)号：US20120089040A1
公开(公告)日：2012-04-12
申请号：US13325654
申请日：2011-12-14
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61B7/00
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more signal processing parameters. The method alters one or more of the parameters as a function of one or more physiologic triggering events. The method then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered signal processing parameters.
摘要翻译： 根据一个或多个信号处理参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。 该方法将一个或多个参数改变为一个或多个生理触发事件的函数。 该方法然后根据至少一个或多个改变的信号处理参数用一个或多个可植入医疗装置感测心脏声音。
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公开(公告)号：US08145590B2
公开(公告)日：2012-03-27
申请号：US12245215
申请日：2008-10-03
CPC分类号： G06N5/04 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B5/053 , A61B5/076 , A61B5/0816 , A61B5/7232 , A61B5/7264 , A61B5/7267 , A61B5/7475 , G06F19/00 , G06N7/005 , G16H50/20 , G16H50/30
摘要： A plurality of chronic sensors are used to facilitate diagnosis and medical decision making for an individual patient. An expert system evaluates the sensor data, combines the sensor data with stored probability data and provides an output signal for notification or medical intervention.
摘要翻译： 使用多个慢性传感器来促进个体患者的诊断和医学决策。 专家系统评估传感器数据，将传感器数据与存储的概率数据组合，并提供用于通知或医疗干预的输出信号。
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9.发明授权公开(公告)号：US08103343B2
公开(公告)日：2012-01-24
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译： 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。
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公开(公告)号：US07972275B2
公开(公告)日：2011-07-05
申请号：US10334694
申请日：2002-12-30
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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