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1.发明授权MAPKs as modifiers of the rac, axin, and beta-catenin pathways and methods of use 失效MAPK作为外消旋，轴突和β-连环蛋白途径的修饰剂和使用方法公开(公告)号：US08067180B2
公开(公告)日：2011-11-29
申请号：US10535571
申请日：2003-11-24
申请人： Lisa C. Kadyk , George Ross Francis , Steven Brian Gendreau , Emery G. Dora, III , Michael R. Costa , Kim Lickteig
发明人： Lisa C. Kadyk , George Ross Francis , Steven Brian Gendreau , Emery G. Dora, III , Michael R. Costa , Kim Lickteig
IPC分类号： G01N33/53
CPC分类号： C12Q1/485 , G01N2500/10
摘要： Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.
摘要翻译： 人MAPK基因被鉴定为Rac，axin和β-连环蛋白途径的调节剂，因此是与有缺陷的Rac，axin和β-连环蛋白功能相关的病症的治疗靶标。 提供了用于鉴定Rac，axin和β-连环蛋白调节剂的方法，包括筛选调节MAPK活性的试剂。
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公开(公告)号：US20110167505A1
公开(公告)日：2011-07-07
申请号：US11993190
申请日：2006-06-20
IPC分类号： A61K49/00 , C12Q1/52 , C12Q1/68 , G01N33/573 , C12N5/071 , A61K39/395 , A61P43/00
CPC分类号： G01N33/57449 , A61K48/00 , C12Q1/48 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N2333/91188
摘要： Human GFAT genes are identified as modulators of the Axin pathway, and thus are therapeutic targets for disorders associated with defective Axin function. Methods for identifying modulators of Axin, comprising screening for agents that modulate the activity of GFAT are provided.
摘要翻译： 人GFAT基因被鉴定为Axin途径的调节剂，因此是与缺陷型Axin功能相关的疾病的治疗靶点。 提供了识别Axin调节剂的方法，包括筛选调节GFAT活性的药剂。
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3.发明授权公开(公告)号：US08003315B2
公开(公告)日：2011-08-23
申请号：US10317835
申请日：2002-12-12
申请人： Michael A. Costa , Steven Brian Gendreau , Emery G. Dora, III , Monique Nicoll , Lenore Urbani , Jeffrey S. Larson
发明人： Michael A. Costa , Steven Brian Gendreau , Emery G. Dora, III , Monique Nicoll , Lenore Urbani , Jeffrey S. Larson
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , G01N33/5011 , G01N2333/4706 , G01N2500/00
摘要： Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.
摘要翻译： 人TAOJIK基因被鉴定为β-连环蛋白途径的调节剂，因此是与β-连环蛋白功能不良相关的疾病的治疗靶点。 提供了鉴定β-连环蛋白调节剂的方法，包括筛选调节TAOJIK活性的药剂。
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4.发明申请Mapks as Modifiers of the Rac, Axin, and Beta-Catenin Pathways and Methods of Use 失效映射作为Rac，Axin和β-联蛋白途径和使用方法的修饰符公开(公告)号：US20080229435A1
公开(公告)日：2008-09-18
申请号：US10535571
申请日：2003-11-24
申请人： Lisa C. Kadyk , George Ross Francis , Steven Brian Gendreau , Emery G. Dora , Michael R. Costa , Kim Lickteig
发明人： Lisa C. Kadyk , George Ross Francis , Steven Brian Gendreau , Emery G. Dora , Michael R. Costa , Kim Lickteig
IPC分类号： A01K67/027 , G01N33/53 , C12Q1/48 , C12N5/06 , C12Q1/68
CPC分类号： C12Q1/485 , G01N2500/10
摘要： Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.
摘要翻译： 人MAPK基因被鉴定为Rac，axin和β-连环蛋白途径的调节剂，因此是与有缺陷的Rac，axin和β-连环蛋白功能相关的病症的治疗靶标。 提供了用于鉴定Rac，axin和β-连环蛋白调节剂的方法，包括筛选调节MAPK活性的试剂。
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