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公开(公告)号:US20140178389A1
公开(公告)日:2014-06-26
申请号:US13940506
申请日:2013-07-12
申请人: Susan E. LACY , Lorenzo BENATUIL , Meha CHHAYA , Emma FUNG , Renee MILLER , Ravi CHARI , Sarah J. HEIGHTON , Jacqueline G. BIXBY
发明人: Susan E. LACY , Lorenzo BENATUIL , Meha CHHAYA , Emma FUNG , Renee MILLER , Ravi CHARI , Sarah J. HEIGHTON , Jacqueline G. BIXBY
IPC分类号: C07K16/24
CPC分类号: C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/60 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.
摘要翻译: 本公开提供了特异性结合IL-1α和IL-1和bgr的结合蛋白。 这些结合蛋白可以组织成DVD-Igs。 这些蛋白质可用于调节IL-1α和/或IL-1和bgr的活性; 并可用于治疗免疫疾病如类风湿性关节炎,骨关节炎,牛皮癣,多发性硬化和其他自身免疫性疾病。 此外,它们在改善和/或治疗患有与IL-1积累相关的疾病或病症的个体中的疼痛的用途。