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公开(公告)号:US08629257B2
公开(公告)日:2014-01-14
申请号:US12763048
申请日:2010-04-19
申请人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号: C07H21/04
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译: 本发明包括IL-12p40结合蛋白,特别是结合人白细胞介素-12(hIL-12)和/或人IL-23(hIL-23)的抗体。 具体地,本发明涉及作为嵌合,CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力,并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性,例如在患有hIL -12和/或hIL-23活性是有害的。
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公开(公告)号:US20100047245A1
公开(公告)日:2010-02-25
申请号:US11478096
申请日:2006-06-29
申请人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号: A61K39/395 , C07K16/18 , C07H21/04 , C12N15/74 , C12N1/21 , C12N5/10 , C12N1/19 , C12N5/071 , A61P37/06
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译: 本发明包括IL-12p40结合蛋白,特别是结合人白细胞介素-12(hIL-12)和/或人IL-23(hIL-23)的抗体。 具体地,本发明涉及作为嵌合,CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力,并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性,例如在患有hIL -12和/或hIL-23活性是有害的。
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公开(公告)号:US08999331B2
公开(公告)日:2015-04-07
申请号:US13659647
申请日:2012-10-24
申请人: Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
发明人: Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
IPC分类号: A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21
CPC分类号: C07K16/468 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/1793 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/19 , A61K38/191 , A61K38/2026 , A61K38/2066 , A61K38/2073 , A61K38/217 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要: Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
摘要翻译: 与用于治疗,预防和诊断硬化性相关疾病的组合物和方法一起描述了结合硬化蛋白或硬化性骨肉瘤和TNF的蛋白质,并用于检测细胞,组织,样品和组合物中的硬化蛋白或硬化性骨肉瘤和TNF。
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公开(公告)号:US20130330348A1
公开(公告)日:2013-12-12
申请号:US13817721
申请日:2011-08-19
申请人: Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
发明人: Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
IPC分类号: C07K16/22
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/566
摘要: The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.
摘要翻译: 本公开内容涵盖NGF结合蛋白,特别是嵌合抗体,CDR移植和标准化抗体的抗体,及其制备和使用方法。 本公开的抗体或抗体部分可用于检测NGF和抑制NGF活性,例如在患有NGF活性有害的病症的哺乳动物受试者中。
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公开(公告)号:US07700739B2
公开(公告)日:2010-04-20
申请号:US11478096
申请日:2006-06-29
申请人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人: Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号: C07K16/00
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译: 本发明包括IL-12p40结合蛋白,特别是结合人白细胞介素-12(hIL-12)和/或人IL-23(hIL-23)的抗体。 具体地,本发明涉及作为嵌合,CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力,并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性,例如在患有hIL -12和/或hIL-23活性是有害的。
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公开(公告)号:US20050227289A1
公开(公告)日:2005-10-13
申请号:US10822306
申请日:2004-04-12
申请人: Edward Reilly , Susan Lacy , Emma Fung , Jonathan Belk , Michael Roguska
发明人: Edward Reilly , Susan Lacy , Emma Fung , Jonathan Belk , Michael Roguska
CPC分类号: C07K16/2863 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2317/92
摘要: The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.
摘要翻译: 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分,治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。
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公开(公告)号:US20110150861A1
公开(公告)日:2011-06-23
申请号:US12914556
申请日:2010-10-28
申请人: Gerald R. Carson , Wendy R. Gion , Yune Z. Kunes , Walter F. Leise, III , Rachel A. Davis-Taber , Emma Fung
发明人: Gerald R. Carson , Wendy R. Gion , Yune Z. Kunes , Walter F. Leise, III , Rachel A. Davis-Taber , Emma Fung
IPC分类号: A61K39/395 , C12N15/63 , C12N1/00 , C12N1/21 , C12N1/11 , C12N5/10 , C12N1/19 , C12N1/15 , C12P21/00 , C07K16/00 , C07K16/24 , A61K38/00 , A61P43/00
CPC分类号: C07K16/00 , C07K16/241 , C07K16/244 , C07K2317/14 , C07K2317/21 , C07K2317/76 , C07K2319/50 , C07K2319/92
摘要: Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF). An embodiment provides an isolated or purified expression vector for generating one or more recombinant protein products comprising a single open reading frame insert; said insert comprising a signal peptide nucleic acid sequence encoding a signal peptide; a first nucleic acid sequence encoding a first polypeptide; a first intervening nucleic acid sequence encoding a first protein cleavage site, wherein said first protein cleavage site is provided by an intein segment of a Ion protease gene of Pyrococcus or a klbA gene of Pyrococcus or Methanococcus, or a modified intein segment derived therefrom; and a second nucleic acid sequence encoding a second polypeptide. Certain embodiments of constructs and methods employ an intein segment of a Ion protease gene of Pyrococcus abyssi, Pyrococcus furiosus, or Pyrococcus horikoshii OT3; or an intein segment of a klbA gene of Pyrococcus abyssi, Pyrococcus furiosus, or Methanococcus jannaschii; or other intein segment.
摘要翻译: 本发明的实施方案涉及用于表达多肽的载体构建体和方法,包括多聚体产物,例如治疗性抗体。 特定结构允许从单个开放阅读框(sORF)生成表达产物。 一个实施方案提供了用于产生一种或多种包含单个开放阅读框插入物的重组蛋白产物的分离或纯化的表达载体; 所述插入片段包含编码信号肽的信号肽核酸序列; 编码第一多肽的第一核酸序列; 编码第一蛋白切割位点的第一插入核酸序列,其中所述第一蛋白切割位点由Pyrococcus的离子蛋白酶基因的内含肽片段或Pyrococcus或Methanococcus的klbA基因或由其衍生的修饰的内含肽片段提供; 和编码第二多肽的第二核酸序列。 构建体和方法的某些实施方案采用激烈球菌(Pyrococcus abyssi),激烈火球菌(Pyrococcus furiosus)或火球菌(Pyrococcus horikoshii)OT3的离子蛋白酶基因的内含肽片段; 或激烈球菌(Crrococcus abyssi),激烈火球菌(Pyrococcus furiosus)或季戊糖(Methanococcus jannaschii)的klbA基因的内含肽片段; 或其他内含肽片段。
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公开(公告)号:US20100196315A1
公开(公告)日:2010-08-05
申请号:US12763048
申请日:2010-04-19
申请人: Susan E. LACY , Emma FUNG , Jonathan P. BELK , Richard W. DIXON , Michael ROGUSKA , Paul R. HINTON , Shankar KUMAR
发明人: Susan E. LACY , Emma FUNG , Jonathan P. BELK , Richard W. DIXON , Michael ROGUSKA , Paul R. HINTON , Shankar KUMAR
IPC分类号: A61K39/395 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12P21/00 , C07K14/00 , A61P29/00 , A61P3/10 , A61P17/04 , A61P9/12 , A61K38/20
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译: 本发明包括IL-12p40结合蛋白,特别是结合人白细胞介素-12(hIL-12)和/或人IL-23(hIL-23)的抗体。 具体地,本发明涉及作为嵌合,CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力,并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性,例如在患有hIL -12和/或hIL-23活性是有害的。
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公开(公告)号:US09505829B2
公开(公告)日:2016-11-29
申请号:US13817721
申请日:2011-08-19
申请人: Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
发明人: Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
IPC分类号: C07K16/22 , A61K39/395
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/566
摘要: The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.
摘要翻译: 本公开内容涵盖NGF结合蛋白,特别是嵌合抗体,CDR移植和标准化抗体的抗体,及其制备和使用方法。 本公开的抗体或抗体部分可用于检测NGF和抑制NGF活性,例如在患有NGF活性有害的病症的哺乳动物受试者中。
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公开(公告)号:US20140178389A1
公开(公告)日:2014-06-26
申请号:US13940506
申请日:2013-07-12
申请人: Susan E. LACY , Lorenzo BENATUIL , Meha CHHAYA , Emma FUNG , Renee MILLER , Ravi CHARI , Sarah J. HEIGHTON , Jacqueline G. BIXBY
发明人: Susan E. LACY , Lorenzo BENATUIL , Meha CHHAYA , Emma FUNG , Renee MILLER , Ravi CHARI , Sarah J. HEIGHTON , Jacqueline G. BIXBY
IPC分类号: C07K16/24
CPC分类号: C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/60 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.
摘要翻译: 本公开提供了特异性结合IL-1α和IL-1和bgr的结合蛋白。 这些结合蛋白可以组织成DVD-Igs。 这些蛋白质可用于调节IL-1α和/或IL-1和bgr的活性; 并可用于治疗免疫疾病如类风湿性关节炎,骨关节炎,牛皮癣,多发性硬化和其他自身免疫性疾病。 此外,它们在改善和/或治疗患有与IL-1积累相关的疾病或病症的个体中的疼痛的用途。
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