公开(公告)号：US20150087672A1

公开(公告)日：2015-03-26

申请号：US14399251

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: C07D491/048

CPC classification number: C07D491/048 ,  C07D519/00

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US09440987B2

公开(公告)日：2016-09-13

申请号：US14399251

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: A61P43/00 ,  C07D519/00 ,  C07D491/048 ,  A61P3/04 ,  A61K31/4355

CPC classification number: C07D491/048 ,  C07D519/00

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US20150111894A1

公开(公告)日：2015-04-23

申请号：US14399396

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。

公开(公告)号：US20160237087A1

公开(公告)日：2016-08-18

申请号：US15139531

申请日：2016-04-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US20150099777A1

公开(公告)日：2015-04-09

申请号：US14505907

申请日：2014-10-03

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US09751878B2

公开(公告)日：2017-09-05

申请号：US15139531

申请日：2016-04-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

公开(公告)号：US09505772B2

公开(公告)日：2016-11-29

申请号：US14399396

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: A61K31/50 ,  C07D491/048

CPC classification number: C07D491/048

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US20150119412A1

公开(公告)日：2015-04-30

申请号：US14525593

申请日：2014-10-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Takashi Nakahata ,  Asato Kina ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Yoichi Nishikawa

IPC: C07D401/12 ,  C07D239/22 ,  C07D211/86

CPC classification number: C07D401/12 ,  C07D211/86 ,  C07D239/22 ,  C07D401/04 ,  C07D401/14

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐的用途作为预防或治疗 提供糖尿病。

公开(公告)号：US20150018363A1

公开(公告)日：2015-01-15

申请号：US14371824

申请日：2013-01-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Tsuyoshi Maekawa ,  Keiko Kakegawa ,  Tsuneo Yasuma ,  Asato Kina ,  Jumpei Aida ,  Uttam Khamrai ,  Mrinalkanti Kundu

IPC: C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D405/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。

公开(公告)号：US09605000B2

公开(公告)日：2017-03-28

申请号：US14775265

申请日：2014-03-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Masaki Ogino ,  Ryo Mizojiri ,  Takeshi Yamasaki ,  Hideki Hirose ,  Nobuyuki Takakura ,  Tohru Yamashita ,  Sachie Morimoto ,  Takashi Nakahata ,  Asato Kina

IPC: C07D498/10 ,  A61P3/00 ,  A61K31/424

CPC classification number: C07D498/10

Abstract: Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.