公开(公告)号：US10968231B2

公开(公告)日：2021-04-06

申请号：US16497141

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  SCOHIA PHARMA, INC

Inventor： Seiji Miwatashi ,  Yasufumi Miyamoto ,  Koji Watanabe ,  Yayoi Nakayama ,  Yuko Hitomi ,  Jumpei Aida ,  Nobuyuki Takakura ,  Hideki Furukawa ,  Naoyoshi Noguchi ,  Yasuhiro Hirata ,  Shizuo Kasai ,  Toshitake Kobayashi ,  Tsuyoshi Maekawa ,  Satoshi Sasaki ,  Shigemitsu Matsumoto

IPC: C07D491/052 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14

Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.

公开(公告)号：US20160237087A1

公开(公告)日：2016-08-18

申请号：US15139531

申请日：2016-04-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US20150099777A1

公开(公告)日：2015-04-09

申请号：US14505907

申请日：2014-10-03

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US09440987B2

公开(公告)日：2016-09-13

申请号：US14399251

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: A61P43/00 ,  C07D519/00 ,  C07D491/048 ,  A61P3/04 ,  A61K31/4355

CPC classification number: C07D491/048 ,  C07D519/00

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US20150111894A1

公开(公告)日：2015-04-23

申请号：US14399396

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。

公开(公告)号：US09487509B2

公开(公告)日：2016-11-08

申请号：US14055585

申请日：2013-10-16

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Tomohiro Kaku ,  Masahiro Kamaura

IPC: C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/22 ,  C07D211/44 ,  C07D211/46 ,  C07D211/78 ,  C07D211/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/04 ,  C07D417/06 ,  C07D413/08 ,  C07D417/04 ,  C07D417/08 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D417/04 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/22 ,  C07D211/44 ,  C07D211/46 ,  C07D211/78 ,  C07D211/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/06 ,  C07D417/08 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.

公开(公告)号：US20150087672A1

公开(公告)日：2015-03-26

申请号：US14399251

申请日：2013-05-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Asato Kina

IPC: C07D491/048

CPC classification number: C07D491/048 ,  C07D519/00

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

公开(公告)号：US10968178B2

公开(公告)日：2021-04-06

申请号：US16496530

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshito Terao ,  Masashi Takahashi ,  Ryoma Hara ,  Kousuke Hidaka ,  Hideki Furukawa ,  Takeshi Yamasaki ,  Shizuo Kasai

IPC: C07D209/96 ,  C07D401/12 ,  C07D403/12 ,  C07D471/10 ,  C07D491/052 ,  A61P3/10 ,  A61P9/04

Abstract: The present invention aims to provide a heterocyclic compound having an IP6K inhibitory action and expected to be useful as a prophylactic or therapeutic agent for—diseases such as cardiac failure, diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the SPECIFICATION, or a salt thereof has an IP6K inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for diseases such as cardiac failure, diabetes and the like.

公开(公告)号：US09605000B2

公开(公告)日：2017-03-28

申请号：US14775265

申请日：2014-03-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Masaki Ogino ,  Ryo Mizojiri ,  Takeshi Yamasaki ,  Hideki Hirose ,  Nobuyuki Takakura ,  Tohru Yamashita ,  Sachie Morimoto ,  Takashi Nakahata ,  Asato Kina

IPC: C07D498/10 ,  A61P3/00 ,  A61K31/424

CPC classification number: C07D498/10

Abstract: Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.

公开(公告)号：US09365540B2

公开(公告)日：2016-06-14

申请号：US14371824

申请日：2013-01-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideyuki Igawa ,  Masashi Takahashi ,  Tsuyoshi Maekawa ,  Keiko Kakegawa ,  Asato Kina ,  Jumpei Aida ,  Uttam Khamrai ,  Mrinalkanti Kundu

IPC: C07D471/04 ,  C07D409/14 ,  C07D405/14 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04 ,  C07D417/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物，可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐，其中每个符号如本说明书中所定义。