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公开(公告)号:US20150087672A1
公开(公告)日:2015-03-26
申请号:US14399251
申请日:2013-05-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Asato Kina
IPC: C07D491/048
CPC classification number: C07D491/048 , C07D519/00
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
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公开(公告)号:US09505772B2
公开(公告)日:2016-11-29
申请号:US14399396
申请日:2013-05-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Asato Kina
IPC: A61K31/50 , C07D491/048
CPC classification number: C07D491/048
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
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公开(公告)号:US09115136B2
公开(公告)日:2015-08-25
申请号:US14059868
申请日:2013-10-22
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Tsuyoshi Maekawa , Hideyuki Igawa
IPC: A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519
Abstract: Provided is a novel compound represented by the following formula wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.
Abstract translation: 本发明提供一种下式表示的新化合物,其中各符号如说明书中所定义,或其盐,其具有血管紧张素II受体拮抗作用和过氧化物酶体增殖物激活受体γ激动活性,可用作试剂 用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。
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4.
公开(公告)号:US20150018363A1
公开(公告)日:2015-01-15
申请号:US14371824
申请日:2013-01-11
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Tsuyoshi Maekawa , Keiko Kakegawa , Tsuneo Yasuma , Asato Kina , Jumpei Aida , Uttam Khamrai , Mrinalkanti Kundu
IPC: C07D401/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D405/14
CPC classification number: C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物,可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐,其中每个符号如本说明书中所定义。
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公开(公告)号:US09440987B2
公开(公告)日:2016-09-13
申请号:US14399251
申请日:2013-05-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Asato Kina
IPC: A61P43/00 , C07D519/00 , C07D491/048 , A61P3/04 , A61K31/4355
CPC classification number: C07D491/048 , C07D519/00
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
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公开(公告)号:US09199963B2
公开(公告)日:2015-12-01
申请号:US14325564
申请日:2014-07-08
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Hideyuki Igawa , Masashi Takahashi , Keiko Kakegawa , Minoru Ikoma , Jumpei Aida
IPC: C07D401/00 , A61K31/4965 , C07D401/04 , C07D401/14 , C07D409/14 , C07D417/14 , C07D405/14
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
Abstract: Provided is a compound having a melanin-concentrating hormone receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of obesity and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 提供具有黑色素浓集激素受体拮抗作用的化合物,并且可用作预防或治疗肥胖症等的药剂。 由式(I)表示的化合物或其盐,其中每个符号如说明书中所定义。
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公开(公告)号:US20150111894A1
公开(公告)日:2015-04-23
申请号:US14399396
申请日:2013-05-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Asato Kina
IPC: C07D491/048
CPC classification number: C07D491/048
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物,可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐,其中每个符号如本说明书中所定义。
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8.
公开(公告)号:US09365540B2
公开(公告)日:2016-06-14
申请号:US14371824
申请日:2013-01-11
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Shizuo Kasai , Hideyuki Igawa , Masashi Takahashi , Tsuyoshi Maekawa , Keiko Kakegawa , Asato Kina , Jumpei Aida , Uttam Khamrai , Mrinalkanti Kundu
IPC: C07D471/04 , C07D409/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14
CPC classification number: C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供具有黑色素浓缩激素受体拮抗作用的芳香环化合物,可用作预防或治疗肥胖症等的药剂。 本发明涉及由下式表示的化合物或其盐,其中每个符号如本说明书中所定义。
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公开(公告)号:US20140046056A1
公开(公告)日:2014-02-13
申请号:US14059868
申请日:2013-10-22
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Tsuyoshi Maekawa , Hideyuki Igawa
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/519
Abstract: Provided is a novel compound represented by the following formula wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.
Abstract translation: 提供了由下式表示的新化合物,其中每个符号如说明书中所定义,或其盐,其具有血管紧张素II受体拮抗活性和过氧化物酶体增殖物激活受体γ激动活性,并且可用作试剂 用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。
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