公开(公告)号：US20180044472A1

公开(公告)日：2018-02-15

申请号：US15727760

申请日：2017-10-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa YAMANO ,  Toshiaki NAGATA ,  Hideki SAITOH

IPC: C08G69/48 ,  C08G69/10 ,  A61K39/39 ,  C08L77/04 ,  A61K47/34 ,  C08G69/08 ,  A61K39/00

CPC classification number: C08G69/48 ,  A61K39/39 ,  A61K47/34 ,  A61K47/42 ,  A61K2039/55555 ,  A61K2039/6093 ,  C08G69/08 ,  C08G69/10 ,  C08L77/04

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

公开(公告)号：US20160177032A1

公开(公告)日：2016-06-23

申请号：US14392185

申请日：2014-06-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa YAMANO ,  Toshiaki NAGATA ,  Hideki SAITOH

IPC: C08G69/48 ,  A61K39/39

CPC classification number: C08G69/48 ,  A61K39/39 ,  A61K47/34 ,  A61K2039/55555 ,  A61K2039/6093 ,  C08G69/08 ,  C08G69/10 ,  C08L77/04

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract translation: 本发明涉及聚（氨基酸）或其盐与疏水性伯胺化合物或其盐的接枝共聚物（例如聚（γ-谷氨酸）的接枝共聚物（γ-PGA-PAE） （γ-PGA）和苯丙氨酸乙酯（PAE）），聚（氨基酸）或其盐和疏水性伯胺化合物或其盐的电离接枝共聚物，含有电离接枝共聚物的纳米粒子，以及生产 方法。 以这种方式获得的纳米颗粒可用作生产疫苗的佐剂。