公开(公告)号：US20180044472A1

公开(公告)日：2018-02-15

申请号：US15727760

申请日：2017-10-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa YAMANO ,  Toshiaki NAGATA ,  Hideki SAITOH

IPC: C08G69/48 ,  C08G69/10 ,  A61K39/39 ,  C08L77/04 ,  A61K47/34 ,  C08G69/08 ,  A61K39/00

CPC classification number: C08G69/48 ,  A61K39/39 ,  A61K47/34 ,  A61K47/42 ,  A61K2039/55555 ,  A61K2039/6093 ,  C08G69/08 ,  C08G69/10 ,  C08L77/04

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

公开(公告)号：US20160177032A1

公开(公告)日：2016-06-23

申请号：US14392185

申请日：2014-06-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Mitsuhisa YAMANO ,  Toshiaki NAGATA ,  Hideki SAITOH

IPC: C08G69/48 ,  A61K39/39

CPC classification number: C08G69/48 ,  A61K39/39 ,  A61K47/34 ,  A61K2039/55555 ,  A61K2039/6093 ,  C08G69/08 ,  C08G69/10 ,  C08L77/04

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract translation: 本发明涉及聚（氨基酸）或其盐与疏水性伯胺化合物或其盐的接枝共聚物（例如聚（γ-谷氨酸）的接枝共聚物（γ-PGA-PAE） （γ-PGA）和苯丙氨酸乙酯（PAE）），聚（氨基酸）或其盐和疏水性伯胺化合物或其盐的电离接枝共聚物，含有电离接枝共聚物的纳米粒子，以及生产 方法。 以这种方式获得的纳米颗粒可用作生产疫苗的佐剂。

公开(公告)号：US20170081305A1

公开(公告)日：2017-03-23

申请号：US15125299

申请日：2015-03-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masatoshi Yamada ,  Sayuri HIRANO ,  Ryoji TSURUOKA ,  Mitsuhisa YAMANO

IPC: C07D401/04 ,  B01J31/24 ,  C07F15/00 ,  C07F17/02 ,  C07D211/78 ,  C07D211/60

CPC classification number: C07D401/04 ,  B01J31/2226 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/842 ,  B01J2540/225 ,  C07B2200/07 ,  C07D211/60 ,  C07D211/78 ,  C07F9/5027 ,  C07F15/0046 ,  C07F17/02

Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative.The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.

公开(公告)号：US20140171655A1

公开(公告)日：2014-06-19

申请号：US14183827

申请日：2014-02-19

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Mitsuhisa YAMANO ,  Mitsutaka GOTO ,  Shinji KAWAGUCHI ,  Masatoshi YAMADA ,  Jun-ichi KAWAKAMI

IPC: C07F9/50 ,  C07F9/572

CPC classification number: C07F9/572 ,  B01J31/2452 ,  B01J2531/80 ,  C07B53/00 ,  C07F9/5022 ,  C07F9/5027 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/0066 ,  C07F15/008

Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions.A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).

Abstract translation: 本发明提供了由下式表示的新型配位体和具有配位体的新型过渡金属络合物，其在各种不对称合成反应中表现出优异的对映体选择性和催化效率，特别高的催化剂活性。 一种具有下式表示的化合物作为配体的过渡金属配合物，其中R 4为氢原子或任选具有取代基的C 1-6烷基，R 5和R 6各自为任选具有 取代基，或式为由下式表示的基团：其中环B为任选具有取代基的3-至8-元环。