公开(公告)号：US11299533B2

公开(公告)日：2022-04-12

申请号：US16015452

申请日：2018-06-22

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Meinhard Hasslacher ,  Martin Feichtinger ,  Philipp M. Bärnthaler ,  Christa Mayer ,  Birgit Reipert ,  Mantas Malisauskas ,  Julia Anzengruber

IPC: C07K14/755 ,  B01D15/32 ,  B01D15/36 ,  B01D15/34 ,  C07K1/16 ,  C07K1/18 ,  C07K1/36 ,  A61K38/00

Abstract: The present invention relates to a method for purifying a Factor VIII (FVIII) subspecies from a composition comprising FVIII, said method comprising an anion exchange chromatography step, a size exclusion chromatography step, and a concentration step. The invention also relates to a composition comprising a purified FVIII subspecies.

公开(公告)号：US20220275058A1

公开(公告)日：2022-09-01

申请号：US17688588

申请日：2022-03-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Meinhard Hasslacher ,  Martin Feichtinger ,  Philipp M. Bärnthaler ,  Christa Mayer ,  Birgit Reipert ,  Mantas Malisauskas ,  Julia Anzengruber

IPC: C07K14/755 ,  B01D15/32 ,  B01D15/36 ,  B01D15/34 ,  C07K1/16 ,  C07K1/18 ,  C07K1/36

Abstract: The present invention relates to a method for purifying a Factor VIII (FVIII) subspecies from a composition comprising FVIII, said method comprising an anion exchange chromatography step, a size exclusion chromatography step, and a concentration step. The invention also relates to a composition comprising a purified FVIII subspecies.

公开(公告)号：US12071468B2

公开(公告)日：2024-08-27

申请号：US17688588

申请日：2022-03-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Meinhard Hasslacher ,  Martin Feichtinger ,  Philipp M. Bärnthaler ,  Christa Mayer ,  Birgit Reipert ,  Mantas Malisauskas ,  Julia Anzengruber

IPC: C07K14/755 ,  A61K38/00 ,  B01D15/32 ,  B01D15/34 ,  B01D15/36 ,  C07K1/16 ,  C07K1/18 ,  C07K1/36

CPC classification number: C07K14/755 ,  B01D15/327 ,  B01D15/34 ,  B01D15/363 ,  C07K1/16 ,  C07K1/18 ,  C07K1/36 ,  A61K38/00 ,  B01D15/363 ,  B01D15/34 ,  B01D15/363 ,  B01D15/327 ,  B01D15/34

Abstract: The present invention relates to a method for purifying a Factor VIII (FVIII) subspecies from a composition comprising FVIII, said method comprising an anion exchange chromatography step, a size exclusion chromatography step, and a concentration step. The invention also relates to a composition comprising a purified FVIII subspecies.