公开(公告)号：US11906519B2

公开(公告)日：2024-02-20

申请号：US16321745

申请日：2017-07-27

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Chengcheng Zhang ,  Zhiqiang An ,  Ningyan Zhang ,  Mi Deng ,  Jaehyup Kim ,  Xun Gui

IPC: G01N33/574 ,  G01N15/14 ,  G01N21/64 ,  G01N33/50 ,  G01N33/49 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N33/57426 ,  G01N15/14 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/4915 ,  G01N33/5023 ,  G01N33/57492 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2021/6439

Abstract: Provided herein are methods and compositions for the identification of modulators of ApoE-induced LILRB activation. Also provided herein are methods of treating cancer comprising the administration of an inhibitor of ApoE-induced LILRB activation. Also provided are methods of treating autoimmune disease or inhibiting the onset of transplant rejection or treating an inflammatory disorder comprising administering an agonist of ApoE-induced LILRB activation to a subject.