公开(公告)号：US11965831B2

公开(公告)日：2024-04-23

申请号：US16976946

申请日：2019-03-01

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Juliet T. Gopinath ,  Brendan M. Heffernan ,  Robert Niederriter ,  Stephanie A. Meyer ,  Diego Restrepo ,  Emily A. Gibson ,  Mark E. Siemens

IPC: G01N21/64 ,  G02B3/00 ,  G02B21/00 ,  G02B27/58

CPC classification number: G01N21/6458 ,  G02B3/0087 ,  G02B21/0032 ,  G02B21/0068 ,  G02B21/0076 ,  G02B27/58 ,  G01N2021/6484

Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.

公开(公告)号：US20200073100A1

公开(公告)日：2020-03-05

申请号：US16557935

申请日：2019-08-30

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Emily A. Gibson ,  Cristin Welle ,  Diego Restrepo ,  Douglas Shepherd ,  Juliet T. Gopinath ,  Victor M. Bright ,  Robert H. Cormack ,  loannis Kymissis

IPC: G02B21/00 ,  G02B27/02

Abstract: The present disclosure provides methods and systems for modulation and imaging of tissue. Various embodiments relate to optical interfaces and methods for rapid volumetric neural sensing and modulation, using structured illumination and

公开(公告)号：US11828680B2

公开(公告)日：2023-11-28

申请号：US16976946

申请日：2019-03-01

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Juliet T. Gopinath ,  Brendan M. Heffernan ,  Robert Niederriter ,  Stephanie A. Meyer ,  Diego Restrepo ,  Emily A. Gibson ,  Mark E. Siemens

IPC: G01N21/64 ,  G02B3/00 ,  G02B21/00 ,  G02B27/58

CPC classification number: G01N21/6458 ,  G02B3/0087 ,  G02B21/0032 ,  G02B21/0068 ,  G02B21/0076 ,  G02B27/58 ,  G01N2021/6484

Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.

公开(公告)号：US11675181B2

公开(公告)日：2023-06-13

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B23/24 ,  G02B26/00 ,  H04N23/56 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/006 ,  G02B21/0032 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US20170010456A1

公开(公告)日：2017-01-12

申请号：US15113303

申请日：2015-01-22

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo

IPC: G02B23/24 ,  G02B21/00 ,  H04N5/225 ,  G02B3/14 ,  G02B6/06 ,  G02B23/26 ,  G02B26/00

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/0032 ,  G02B21/006 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N5/2256 ,  H04N2005/2255

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

Abstract translation: 本公开涉及在生物和医学成像应用中有用的光学成像装置和方法。 在一个实施例中，光学成像装置包括具有第一端和第二端的柔性光导，脉冲红外辐射源的输出光耦合到柔性光导的第一端; 透镜组件，其附接到光学耦合到柔性光导的第二端，所述透镜组件包括可变焦距透镜元件，所述可变焦距透镜元件具有可调焦距; 以及耦合到柔性光导以检测从柔性光导的第二端朝向第一端传播的辐射的光电检测器。 光学成像装置和方法可以用于共聚焦和多光子技术。

公开(公告)号：US11971535B2

公开(公告)日：2024-04-30

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B6/06 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/00 ,  H04N23/56 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/0032 ,  G02B21/006 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US11835706B2

公开(公告)日：2023-12-05

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B23/24 ,  G02B26/00 ,  H04N23/56 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/006 ,  G02B21/0032 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US10900874B2

公开(公告)日：2021-01-26

申请号：US15527217

申请日：2015-11-19

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Gregory Futia ,  Emily A. Gibson ,  Kian Behbakht

IPC: G01N1/00 ,  G01N1/31 ,  G06K9/00 ,  G01N1/40

Abstract: Devices and methods for labeling and mounting suspended cells in a controllable area are disclosed. The devices and methods utilize polycarbonate filters. The filters are employed both to capture the cells and as a substrate for labeling. This disclosure provides a device for cell capture and staining. This device utilizes a stack comprising a filter sandwiched between two o-rings (an “OFO stack”) in which the o-rings both seat the device and, based on their outer diameter and cross-section, determine the cell capture area. In one embodiment, an alignment plate is affixed to an output head of the device, the alignment plate having one or more through holes, a diameter of the one or more through holes matching an outer diameter of the OFO stack.

公开(公告)号：US20200348505A1

公开(公告)日：2020-11-05

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B23/24 ,  G02B3/14 ,  G02B26/00 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N5/225

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.