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公开(公告)号:US10799691B2
公开(公告)日:2020-10-13
申请号:US15586447
申请日:2017-05-04
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Daizo Uemura , Kazuhiko Shiomitsu
Abstract: A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.
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公开(公告)号:US10537722B2
公开(公告)日:2020-01-21
申请号:US15404345
申请日:2017-01-12
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Kazuhiko Shiomitsu
IPC: A61M37/00
Abstract: A microneedle including a substrate having a first surface and a second surface opposite to the first surface, at least one piercing projection projecting from the first surface of the substrate and being surrounded by an outer peripheral region of the substrate when viewed in a direction perpendicular to the first surface, and surface-defining structures positioned in the outer peripheral region and including three or more surface-defining structures each having a surface-defining section which is one of a surface-defining projection and a surface-defining recess. The surface-defining projection protrudes from the first surface and has a tip which serves as the surface-defining section, the surface-defining recess is recessed from the first surface and has a bottom serving as the surface-defining section, and the piercing projection has a tip that extends beyond a plane including the surface-defining sections of three surface-defining structures among the surface-defining structures.
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公开(公告)号:US20180117293A1
公开(公告)日:2018-05-03
申请号:US15842085
申请日:2017-12-14
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Kazuhiko Shiomitsu
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B29C45/14336 , B29C45/40 , B29C65/4835 , B29C65/4845 , B29K2101/12 , B29L2031/759 , B81B1/00 , B81C1/00
Abstract: A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method including the steps of: forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles; providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface; and removing the needle-shaped body and the support member which are integrally formed from the duplication plate.
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公开(公告)号:US10300261B2
公开(公告)日:2019-05-28
申请号:US15842085
申请日:2017-12-14
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Kazuhiko Shiomitsu
Abstract: A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method including the steps of: forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles; providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface; and removing the needle-shaped body and the support member which are integrally formed from the duplication plate.
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公开(公告)号:US20180318570A1
公开(公告)日:2018-11-08
申请号:US16037058
申请日:2018-07-17
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Tomoya SUMIDA , Yumiko IKEDA , Masaki KONO , Yoshihiro KODAMA , Kazuhiko Shiomitsu
CPC classification number: A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/003 , F04C2270/0421
Abstract: An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
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公开(公告)号:US10046152B2
公开(公告)日:2018-08-14
申请号:US14689541
申请日:2015-04-17
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Tomoya Sumida , Yumiko Ikeda , Masaki Kono , Yoshihiro Kodama , Kazuhiko Shiomitsu
Abstract: An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
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公开(公告)号:US10926072B2
公开(公告)日:2021-02-23
申请号:US16037058
申请日:2018-07-17
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Tomoya Sumida , Yumiko Ikeda , Masaki Kono , Yoshihiro Kodama , Kazuhiko Shiomitsu
Abstract: An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
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公开(公告)号:US20170232246A1
公开(公告)日:2017-08-17
申请号:US15586447
申请日:2017-05-04
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Daizo Uemura , Kazuhiko Shiomitsu
IPC: A61M37/00
Abstract: A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.
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公开(公告)号:US09238384B2
公开(公告)日:2016-01-19
申请号:US13752959
申请日:2013-01-29
Applicant: TOPPAN PRINTING CO., LTD.
Inventor: Kazuhiko Shiomitsu , Hiroshi Sugimura , Toshiaki Kurosu , Gaku Suzuki , Takao Tomono
CPC classification number: B44C1/227 , A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , B29C33/42 , B81B2201/055 , B81C1/00111 , B81C2201/0198
Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.
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