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公开(公告)号：US20180318570A1
公开(公告)日：2018-11-08
申请号：US16037058
申请日：2018-07-17
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/003 , F04C2270/0421
摘要： An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
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2.发明申请INSTRUMENT FOR MANIPULATING FLUID INJECTOR THAT USES MULTI-MICRONEEDLE DEVICE 审中-公开用于使用多个麦克风装置的流体注射器操作仪表公开(公告)号：US20150217101A1
公开(公告)日：2015-08-06
申请号：US14689541
申请日：2015-04-17
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/003 , F04C2270/0421
摘要： An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
摘要翻译： 用于流体注射器的操作工具包括选择运动机构，该选择运动机构使流体注射器在外筒的壳体中的第一突出位置和第二突出位置之间移动。 当流体注射器处于第一突出位置时，多微针装置的微针从第一开口端突出到第一距离。 当流体注射器处于第二突出位置以通过微针排出流体时，微针从与第一距离短的第一开口端突出到第二距离。 选择运动机构包括旋转线性运动转换机构，其基于外筒相对于流体的方向和旋转量沿着外筒的纵向中心线在第一和第二突出位置之间移动流体喷射器 注射器。
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公开(公告)号：US20190381256A1
公开(公告)日：2019-12-19
申请号：US16552031
申请日：2019-08-27
发明人： Yoshihiro KODAMA
IPC分类号： A61M5/32
摘要： A transdermal administration device includes an administration section and a support body. The administration section includes a base having a base surface and a projection protruding from base surface and having a peripheral surface, the projection including a flow path which extends through the projection to the peripheral surface and is open to the peripheral surface. The support body includes a plurality of support sections configured to abut a target of administration. When viewed in a direction facing base surface, the plurality of support sections surround the base surface with a gap between the adjacent support sections and between the base surface and the support sections. The transdermal administration device is configured to displace the projection relative to the support sections from a position in a space surrounded by the plurality of support sections toward outside the space in an extending direction of the projection.
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公开(公告)号：US20170333691A1
公开(公告)日：2017-11-23
申请号：US15673739
申请日：2017-08-10
发明人： Yoshihiro KODAMA
IPC分类号： A61M37/00 , B29C45/26 , B29L31/00 , B29C45/00 , B29K101/12
CPC分类号： A61M37/0015 , A61M5/46 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B29C45/261 , B29C45/2628 , B29C45/36 , B29C2045/0094 , B29K2101/12 , B29L2031/7544 , B29L2031/756
摘要： A microneedle including a projection having a through hole formed in the projection in a direction that the projection extends, and a tubular member having an end surface configured to support the projection when the end surface is pressed against a skin and a fluid is supplied through the through hole of the projection to the skin. The projection has a length H along the direction that the projection extends and the supporting surface has an area S such that a ratio of S/H is in a range of from 2.1 to 10.5.
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公开(公告)号：US20170021112A1
公开(公告)日：2017-01-26
申请号：US15283563
申请日：2016-10-03
发明人： Yoshihiro KODAMA , Tomoya Sumida
CPC分类号： A61M5/3295 , A61B5/0066 , A61B5/441 , A61B8/0858 , A61B8/4444 , A61B8/4477 , A61B8/461 , A61M5/3158 , A61M5/31581 , A61M5/46 , A61M2005/31588 , A61M2037/0061
摘要： A puncture injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having one or more projections which are formed on the first surface and each have a through hole penetrating from a distal end of the projection to the second surface of the substrate, and one or more probes positioned outside a region where the one or more projections are formed. The one or more probes include an ultrasound probe or an optical coherence tomography probe.
摘要翻译： 1.一种穿刺注射器械，其特征在于，包括具有第一面和与该第一面相对的第二面的基材的中空针体，所述中空针体具有形成在所述第一面上的一个以上突起， 所述突起的远端到所述基板的第二表面，以及位于形成所述一个或多个突起的区域外的一个或多个探针。 一个或多个探针包括超声波探头或光学相干断层摄影探针。
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公开(公告)号：US20190022364A1
公开(公告)日：2019-01-24
申请号：US16003459
申请日：2017-01-19
发明人： Yoshihiro KODAMA
IPC分类号： A61M37/00
摘要： A microneedle includes a base having a support surface, and a projection that protrudes from the support surface, the projection having a through hole that penetrates the projection in an extending direction of the projection. The projection includes a flow path expansion section which is configured to expand a communication path that communicates between an inner space of the through hole and a space surrounding the projection in response to an increase in pressure of a fluid flowing in the through hole.
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公开(公告)号：US20170368322A1
公开(公告)日：2017-12-28
申请号：US15701216
申请日：2017-09-11
申请人： TOPPAN PRINTING CO., LTD. , JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NAT'L INST. OF INFECTIOUS DISEASES
发明人： Hiroyuki KATO , Tomoya SUMIDA , Yoshihiro KODAMA , Seishiro NAITO
IPC分类号： A61M37/00
摘要： A drug administration device includes a substrate having a first surface, a projection extending from the first surface, and a solid drug. One direction that intersects with the first surface is a first direction, and one direction that extends along the first surface is a second direction. A groove serving as a receiving section is formed in the projection. The groove defines a cavity recessed in the first direction toward the substrate and extends in the second direction to open to a section of the peripheral surface of the projection. The drug is received in the groove.
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公开(公告)号：US20210401460A1
公开(公告)日：2021-12-30
申请号：US17467691
申请日：2021-09-07
IPC分类号： A61B17/34
摘要： A cell transplantation device is used to place a graft containing cells into a target region in a living body. The cell transplantation device includes a needle extending in one direction, and a filter unit made of a fibrous member. The needle has a flow channel defined therein and an opening at the tip of the needle. The filter unit is disposed at an intermediate position in the flow channel and configured to retain a graft between the filter unit and the opening when a liquid material containing the graft enters the flow channel through the opening.
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公开(公告)号：US20200222678A1
公开(公告)日：2020-07-16
申请号：US16832260
申请日：2020-03-27
摘要： A cell transplantation device for placing a cell group at a target region in at least one of an intradermal layer and a subcutaneous layer in a living body, including a device body including a protruding portion having an accommodating portion for accommodating a liquid composition including the cell group. The protruding portion has an opening that communicates with the accommodating portion, and the protruding portion penetrates a skin surface of the living body such that the opening of the protruding portion reaches the at least one of the intradermal layer and the subcutaneous layer and that the cell group accommodated in the accommodating portion is placed at the target region through the opening.
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公开(公告)号：US20170021152A1
公开(公告)日：2017-01-26
申请号：US15286833
申请日：2016-10-06
发明人： Yoshihiro KODAMA
摘要： An injection instrument including a hollow needle body including a substrate having a first surface and a second surface opposite to the first surface, the hollow needle body having at least one projection which is formed on the first surface and has a through hole penetrating from a distal end of the projection to the second surface of the substrate, a deforming member positioned outside a region where the at least one projection is formed, the deforming member being deformable to bulge in a bulging direction along a projecting direction of the projection beyond a plane flush with the first surface, and a pressure channel through which a fluid is supplied such that a fluid pressure is applied to the deforming member. The deforming member is deformable in the bulging direction in response to the fluid pressure.
摘要翻译： 一种注射器械，包括具有第一表面和与所述第一表面相对的第二表面的基底的中空针体，所述中空针体具有形成在所述第一表面上的至少一个突起，并且具有从远端 所述突起的端部到所述基板的第二表面，所述变形构件位于形成有所述至少一个突起的区域的外侧，所述变形构件能够沿着所述突起的突出方向沿凸出方向凸出超过平面齐平 和第一表面以及压力通道，通过该压力通道供应流体，使得流体压力施加到变形构件。 变形构件响应于流体压力而在膨胀方向上可变形。
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