公开(公告)号：US09527841B2

公开(公告)日：2016-12-27

申请号：US14414020

申请日：2013-07-12

申请人： Takeda Pharmaceutical Company Limited

发明人： Shinji Nakamura ,  Satoshi Mikami ,  Kawasaki Masanori ,  Izumi Nomura ,  Tomoko Ashizawa ,  Takahiko Taniguchi

IPC分类号： C07D241/38 ,  C07D471/04 ,  C07D235/16

CPC分类号： C07D471/04 ,  C07D235/16

摘要： The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like.The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

摘要翻译： 本发明提供具有PDE2A选择性抑制作用的化合物，其可用作预防或治疗精神分裂症，阿尔茨海默氏病等。 本发明是由式（1）表示的化合物：其中每个符号如说明书中所述或其盐。

公开(公告)号：US09469637B2

公开(公告)日：2016-10-18

申请号：US14397066

申请日：2013-04-24

申请人： Takeda Pharmaceutical Company Limited

发明人： Satoshi Mikami ,  Shinji Nakamura ,  Tomoko Ashizawa ,  Shigekazu Sasaki ,  Takahiko Taniguchi ,  Izumi Nomura ,  Masanori Kawasaki

IPC分类号： C07D241/36 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K9/20 ,  A61K31/498 ,  A61K31/555 ,  C07D519/00 ,  C07F7/1804

摘要： The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like.The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US10017508B2

公开(公告)日：2018-07-10

申请号：US15264213

申请日：2016-09-13

申请人： Takeda Pharmaceutical Company Limited

发明人： Satoshi Mikami ,  Shinji Nakamura ,  Tomoko Ashizawa ,  Shigekazu Sasaki ,  Takahiko Taniguchi ,  Izumi Nomura ,  Masanori Kawasaki

IPC分类号： C07D241/36 ,  A61K31/498 ,  C07D471/04 ,  C07D519/00 ,  A61K9/20 ,  A61K31/555 ,  C07F7/18

CPC分类号： C07D471/04 ,  A61K9/20 ,  A61K31/498 ,  A61K31/555 ,  C07D519/00 ,  C07F7/1804

摘要： The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like.The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20150266872A1

公开(公告)日：2015-09-24

申请号：US14435899

申请日：2013-10-15

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Tomoaki Hasui ,  Haruhi Ando ,  Hiromi Fukuda ,  Toshiya Nishi

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D413/04

CPC分类号： C07D471/04 ,  C07D413/04 ,  C07D519/00

摘要： The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

摘要翻译： 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

公开(公告)号：US20150158863A1

公开(公告)日：2015-06-11

申请号：US14414020

申请日：2013-07-12

申请人： Takeda Pharmaceutical Company Limited

发明人： Shinji Nakamura ,  Satoshi Mikami ,  Kawasaki Masanori ,  Izumi Nomura ,  Tomoko Ashizawa ,  Takahiko Taniguchi

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D235/16

摘要： The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like.The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

摘要翻译： 本发明提供具有PDE2A选择性抑制作用的化合物，其可用作预防或治疗精神分裂症，阿尔茨海默氏病等。 本发明是由式（1）表示的化合物：其中每个符号如说明书中所述或其盐。

公开(公告)号：US09624184B2

公开(公告)日：2017-04-18

申请号：US14781665

申请日：2014-04-03

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Haruhi Ando ,  Tomoaki Hasui ,  Toshiya Nishi

IPC分类号： C07D413/10 ,  C07D491/08 ,  C07D413/12 ,  C07D413/14 ,  C07D263/32 ,  C07D413/04

CPC分类号： C07D263/32 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/08

摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US20160159808A1

公开(公告)日：2016-06-09

申请号：US14907139

申请日：2014-07-23

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Masanori Kawasaki ,  Satoshi Mikami ,  Shinji Nakamura ,  Nobuyuki Negoro ,  Shuhei Ikeda ,  Izumi Nomura ,  Tomoko Ashizawa ,  Toshihiro Imaeda ,  Masaki Seto ,  Shigekazu Sasaki ,  Shogo Marui ,  Takahiko Taniguchi

IPC分类号： C07D487/04 ,  C07D498/08 ,  C07D491/08 ,  C07D471/04 ,  C07D473/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D498/08

摘要： A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

摘要翻译： 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有PDE2A抑制作用，并且可用作精神分裂症，阿尔茨海默氏病等的预防或治疗药物。

公开(公告)号：US09296746B2

公开(公告)日：2016-03-29

申请号：US14435899

申请日：2013-10-15

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Tomoaki Hasui ,  Haruhi Ando ,  Hiromi Fukuda

IPC分类号： C07D413/02 ,  C07D403/02 ,  A61K31/4245 ,  A61K31/416 ,  C07D471/04 ,  C07D519/00 ,  C07D413/04

CPC分类号： C07D471/04 ,  C07D413/04 ,  C07D519/00

摘要： The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

摘要翻译： 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。