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公开(公告)号：US09611244B2
公开(公告)日：2017-04-04
申请号：US15148210
申请日：2016-05-06
IPC分类号： C07D317/72 , C07C317/12 , C07D309/28 , C07C317/44 , C07C317/46
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
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公开(公告)号：US09533966B2
公开(公告)日：2017-01-03
申请号：US15175292
申请日：2016-06-07
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
摘要翻译： （其中，在说明书中更详细地说明每个符号）。
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公开(公告)号：US08598226B2
公开(公告)日：2013-12-03
申请号：US13910374
申请日：2013-06-05
发明人： Tsuneo Yasuma , Nobuyuki Negoro
IPC分类号： A61K31/343
CPC分类号： C07D409/12 , C07D307/80
摘要： The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译： 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。 化合物或其盐或其前药具有GPR40受体功能调节作用，并且可用作胰岛素促分泌素或用于预防或治疗糖尿病等的药剂。
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公开(公告)号：US10738004B2
公开(公告)日：2020-08-11
申请号：US16331962
申请日：2017-09-07
发明人： Toshitake Kobayashi , Morihisa Saitoh , Yasufumi Wada , Nobuyuki Negoro , Masashi Yamasaki , Takahiro Tanaka , Naomi Kitamoto
IPC分类号： C07C317/46 , A61K31/235 , A61P1/16 , A61P9/10 , A61P37/02 , A61P29/00 , A61P25/02 , A61P43/00
摘要： Provided is a compound, such as ethyl 6-((2-chloro-4-fluorobenzyl)sulfonyl) -3-hydroxycyclohex-1-ene-1-carboxylate or an optical isomer thereof, having a superior Toll-like receptor 4 (TLR4) signaling inhibitory action, which may be useful as a prophylactic or therapeutic drug for diseases such as autoimmune diseases and/or inflammatory diseases, or chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver failure, and ischemia reperfusion injury (IRI).
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公开(公告)号：US09828357B2
公开(公告)日：2017-11-28
申请号：US15356906
申请日：2016-11-21
发明人： Toshitake Kobayashi , Morihisa Saitoh , Yasufumi Wada , Hiroshi Nara , Nobuyuki Negoro , Taisuke Katoh , Masashi Yamasaki , Takahiro Tanaka , Naomi Kitamoto
IPC分类号： C07D317/72 , C07C317/12 , C07D309/28 , C07C317/44 , C07C317/46
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.
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公开(公告)号：US20160159808A1
公开(公告)日：2016-06-09
申请号：US14907139
申请日：2014-07-23
发明人： Masanori Kawasaki , Satoshi Mikami , Shinji Nakamura , Nobuyuki Negoro , Shuhei Ikeda , Izumi Nomura , Tomoko Ashizawa , Toshihiro Imaeda , Masaki Seto , Shigekazu Sasaki , Shogo Marui , Takahiko Taniguchi
IPC分类号： C07D487/04 , C07D498/08 , C07D491/08 , C07D471/04 , C07D473/00
CPC分类号： C07D487/04 , C07D471/04 , C07D473/00 , C07D491/08 , C07D498/08
摘要： A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.
摘要翻译： 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有PDE2A抑制作用，并且可用作精神分裂症，阿尔茨海默氏病等的预防或治疗药物。
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