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    Isoquinoline derivatives
    1.
    发明授权
    Isoquinoline derivatives 失效
    异喹啉衍生物

    公开(公告)号：US4782154A

    公开(公告)日：1988-11-01

    申请号：US75828

    申请日：1987-07-17

    申请人： Tatsuo Kaiho ,  Seitaro Kajiya ,  Kengo Otsuka ,  Masahiko Maruyama ,  Makoto Hirayama

    发明人： Tatsuo Kaiho ,  Seitaro Kajiya ,  Kengo Otsuka ,  Masahiko Maruyama ,  Makoto Hirayama

    IPC分类号： A61K31/47 ,  A61P9/00 ,  A61P9/04 ,  C07D401/04 ,  C07D217/16

    CPC分类号： C07D401/04

    摘要： The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: ##STR1## where R.sub.1 represents a lower C.sub.1 -C.sub.4 alkyl group or cyclopropyl group,R.sub.2 represents formyl group, lower C.sub.1 -C.sub.4 alkanoyl group and benzoyl group, lower C.sub.1 -C.sub.4 alkyl group, lower C.sub.1 -C.sub.4 alkenyl group, lower C.sub.1 -C.sub.4 hydroxy substituted alkyl group, C.sub.1 -C.sub.4 perfluoroalkyl group andR.sub.3 represents 4-pyridyl group or 2-pyridyl group respectively,and the therapeutically acceptable salts thereof are also useful as cardiotonics.

    摘要翻译： 由以下通式（I）表示的异喹啉衍生物可用作具有高强度活性和低毒性的强心剂：其中R 1表示低级C 1 -C 4烷基或环丙基，R 2表示甲酰基，低级 C1-C4烷酰基和苯甲酰基，低级C1-C4烷基，低级C1-C4烯基，低级C1-C4羟基取代烷基，C1-C4全氟烷基，R3分别代表4-吡啶基或2-吡啶基 ，其治疗上可接受的盐也可用作强心剂。

    Polyamine derivative and polyol derivative
    4.
    发明授权
    Polyamine derivative and polyol derivative 有权
    多胺衍生物和多元醇衍生物

    公开(公告)号：US08354529B2

    公开(公告)日：2013-01-15

    申请号：US13289013

    申请日：2011-11-04

    申请人： Naruyoshi Mita ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    发明人： Naruyoshi Mita ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    IPC分类号： C07D401/14 ,  C08K5/3492 ,  C08L101/00 ,  C09K15/30

    CPC分类号： C09K15/30 ,  C07D401/14 ,  C07D493/10 ,  C08K5/34926 ,  C09K15/16

    摘要： A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organinc material. Compounds of the general formula: (1) (wherein X is N(R4) or an oxygen atom; R1 is an n-valent hydrocarbon group; R2 is an hydrogen atom or an alkyl; R3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

    摘要翻译： 具有哌啶基氨基三嗪骨架的新型多胺衍生物或多元醇衍生物; 这些化合物的盐; 一个生产它们的过程; 包含任何这些化合物的有机材料稳定剂; 稳定有机材料的方法; 和稳定的有机金属材料。 通式为（1）的化合物（其中X为N（R4）或氧原子; R1为n价烃基; R2为氢原子或烷基; R3为氢原子，烷基， 烷氧基或酰基; R 4为氢原子或烷基，n为3〜16的整数）可有效地抑制有机材料的光，热，氧，臭氧和电磁波的劣化，例如X 射线和γ射线。

    POLYAMINE DERIVATIVE AND POLYOL DERIVATIVE
    5.
    发明申请
    POLYAMINE DERIVATIVE AND POLYOL DERIVATIVE 有权
    聚氨酯衍生物和多元醇衍生物

    公开(公告)号：US20120053270A1

    公开(公告)日：2012-03-01

    申请号：US13289013

    申请日：2011-11-04

    申请人： NARUYOSHI MITA ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    发明人： NARUYOSHI MITA ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    IPC分类号： C08K5/3492 ,  C08L23/06 ,  C08L23/12 ,  C07D401/14 ,  C07D493/10

    CPC分类号： C09K15/30 ,  C07D401/14 ,  C07D493/10 ,  C08K5/34926 ,  C09K15/16

    摘要： A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organinc material. Compounds of the general formula: (1) (wherein X is N(R4) or an oxygen atom; R1 is an n-valent hydrocarbon group; R2 is an hydrogen atom or an alkyl; R3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

    摘要翻译： 具有哌啶基氨基三嗪骨架的新型多胺衍生物或多元醇衍生物; 这些化合物的盐; 一个生产它们的过程; 包含任何这些化合物的有机材料稳定剂; 稳定有机材料的方法; 和稳定的有机金属材料。 通式为（1）的化合物（其中X为N（R4）或氧原子; R1为n价烃基; R2为氢原子或烷基; R3为氢原子，烷基， 烷氧基或酰基; R 4为氢原子或烷基，n为3〜16的整数）可有效地抑制有机材料的光，热，氧，臭氧和电磁波的劣化，例如X 射线和γ射线。

    Process for producing 1-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
    6.
    发明授权
    Process for producing 1-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives 失效
    1-（2'-脱氧-β-D-赤型 - 呋喃戊糖基）-5-三氟甲基尿嘧啶衍生物的制备方法

    公开(公告)号：US5532349A

    公开(公告)日：1996-07-02

    申请号：US275455

    申请日：1994-07-15

    申请人： Nobuya Kawauchi ,  Nobuyuki Fukazawa ,  Hiroki Ishibashi ,  Kengo Otsuka

    发明人： Nobuya Kawauchi ,  Nobuyuki Fukazawa ,  Hiroki Ishibashi ,  Kengo Otsuka

    IPC分类号： C07H19/06 ,  C07H19/073 ,  A61K31/70

    CPC分类号： C07H19/06

    摘要： A process for producing 1-(2'-deoxy-B-D-erythropentofuranosyl)-5-trifluoromethyluracil derivatives having the formula as shown below: ##STR1## wherein X.sup.1 and X.sup.2 are independently hydrogen or halogen, comprising:(a) reacting 5-trifluoromethyl-5,6-dihydrouracil with alkylsulfoxide in the presence of a halogen and and acid to obtain 5-trifluoromethyluracil;(b) reacting the obtained 5-trifluoromethyluracil with a silylating agent to obtain 5-trifluoromethyl-2,4 -bis(trimethylsilyloxy)uracil; and(c) reacting the obtained 5-trifluoromethyl-2,4-bis(trimethylsilyloxy)uracil with a protected 2-deoxyalpha-D-erthro-pentofuranosyl)halide derivative in chloroform solvent in the presence of fluoride ion and in the presence of a copper compound as a catalyst.The resulting, deblocked nucleosides are useful as antiviral and antitumor agents.

    摘要翻译： 一种制备具有下式的1-（2'-脱氧-β-赤式呋喃糖基）-5-三氟甲基尿嘧啶衍生物的方法：其中X1和X2独立地是氢或卤素，包括：（a）使5-三氟甲基 -5,6-二氢尿嘧啶与烷基亚砜在卤素存在下反应，得到5-三氟甲基尿嘧啶; （b）使所得5-三氟甲基尿嘧啶与甲硅烷基化试剂反应，得到5-三氟甲基-2,4-双（三甲基甲硅烷氧基）尿嘧啶; 和（c）使得到的5-三氟甲基-2,4-双（三甲基甲硅烷氧基）尿嘧啶与受保护的2-脱氧-α-D-戊硫基呋喃糖基）卤化物衍生物在氯仿溶剂中，在氟离子存在下，在 铜化合物作为催化剂。 所得到的解封核苷可用作抗病毒和抗肿瘤剂。

    Process for production of glycide derivative
    8.
    发明授权
    Process for production of glycide derivative 失效
    制备糖苷衍生物的方法

    公开(公告)号：US5463061A

    公开(公告)日：1995-10-31

    申请号：US175397

    申请日：1994-01-13

    申请人： Nobuyuki Fukazawa ,  Tsuneji Suzuki ,  Nobuya Kawauchi ,  Hironori Komatsu ,  Kengo Otsuka ,  Yuki Nakajima

    发明人： Nobuyuki Fukazawa ,  Tsuneji Suzuki ,  Nobuya Kawauchi ,  Hironori Komatsu ,  Kengo Otsuka ,  Yuki Nakajima

    IPC分类号： C07D303/22 ,  C07D303/23 ,  C07D405/12 ,  C07D215/20

    CPC分类号： C07D303/22 ,  C07D405/12

    摘要： A glycide derivative represented by the following general formula (I) is produced by reacting a hydroxyaryl or heteroaryl represented by A-OH with glycidyl tosylate in the presence of a cesium base as a base. Thereby, an aryl glycidyl ether derivative, which is an important intermediate for drug production, can be produced easily and reliably. Particularly when optically active glycidyl tosylate is used, said compound can be obtained at a high optical purity. ##STR1## wherein A represents an aryl group or a heteroaryl group.

    摘要翻译： PCT No.PCT / JP93 / 00626 Sec。 371日期1994年1月13日 102（e）日期1994年1月13日PCT提交1993年5月13日PCT公布。 公开号WO93 / 23386 日期：1月25日。由以下通式（I）表示的糖苷衍生物是通过使羟基芳基或由A-OH表示的杂芳基与甲苯磺酸缩水甘油酯在铯基作为碱的存在下反应制备的。 因此，可以容易且可靠地制造作为药物生产的重要中间体的芳基缩水甘油醚衍生物。 特别是当使用光学活性的甲苯磺酸缩水甘油酯时，可以高光学纯度获得所述化合物。 （I）其中A表示芳基或杂芳基。

    Polyamine derivative and polyol derivative
    10.
    发明授权
    Polyamine derivative and polyol derivative 有权
    多胺衍生物和多元醇衍生物

    公开(公告)号：US08076478B2

    公开(公告)日：2011-12-13

    申请号：US11795216

    申请日：2006-01-18

    申请人： Naruyoshi Mita ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    发明人： Naruyoshi Mita ,  Mitsuaki Chida ,  Masaru Kawaguchi ,  Kengo Otsuka ,  Naoshi Nagai ,  Takaaki Yamazaki ,  Tetsuya Ichihashi

    IPC分类号： C07D401/14 ,  C08K5/3492 ,  C08L101/00 ,  C09K15/30

    CPC分类号： C09K15/30 ,  C07D401/14 ,  C07D493/10 ,  C08K5/34926 ,  C09K15/16

    摘要： A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton; salts of such compounds; a process for producing them; an organic material stabilizer comprising any of such compounds; a method of stabilizing an organic material; and a stabilized organic material. Compounds of the general formula: (1) (wherein X is N(R4) or an oxygen atom; R1 is an n-valent hydrocarbon group; R2 is a hydrogen atom or an alkyl; R3 is a hydrogen atom, an alkyl, an alkoxy or an acyl; R4 is a hydrogen atom or an alkyl; and n is an integer of 3 to 16) are effective in the stabilization of an organic material against deterioration by light, heat, oxygen, ozone and electromagnetic waves, such as X-rays and γ-rays.

    摘要翻译： 具有哌啶基氨基三嗪骨架的新型多胺衍生物或多元醇衍生物; 这些化合物的盐; 一个生产它们的过程; 包含任何这些化合物的有机材料稳定剂; 稳定有机材料的方法; 和稳定的有机材料。 通式（1）的化合物（其中X为N（R4）或氧原子; R1为n价烃基; R2为氢原子或烷基; R3为氢原子，烷基， 烷氧基或酰基; R 4为氢原子或烷基，n为3〜16的整数）可有效地抑制有机材料的光，热，氧，臭氧和电磁波的劣化，例如X 射线和γ射线。