专利检索 ap:("The U.S.A., as represented by the Secretary, Department of Health AND Human Services") AND inv:"Amanda E. Calvert" 第 1 页

1.

发明申请
RAPID DETECTION OF ZIKA VIRUS BY REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION 审中-公开

公开(公告)号：US20200063216A1

公开(公告)日：2020-02-27

申请号：US16609994

申请日：2018-04-27

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Amanda E. Calvert

IPC分类号： C12Q1/6888 , C12Q1/70 , C12Q1/6844

摘要： A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per μl and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.

2.

发明申请
MONOCLONAL ANTIBODIES SPECIFIC FOR HEARTLAND VIRUS AND METHODS OF THEIR USE 审中-公开

公开(公告)号：US20180244757A1

公开(公告)日：2018-08-30

申请号：US15761789

申请日：2016-01-12

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Amanda E. Calvert , Aaron C. Brault

IPC分类号： C07K16/10 , G01N33/569

CPC分类号： C07K16/10 , A61K39/12 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , C07K2319/00 , C12N2760/12211 , G01N33/56983 , G01N2333/175 , G01N2469/20

摘要： Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for example, in immunoassays to detect HRTV-specific antibodies in a biological sample or to detect HRTV in a cell or tissue sample. The monoclonal antibodies can also be used to diagnose or treat an HRTV infection.

3.

发明授权
Rapid detection of Zika virus by reverse transcription loop-mediated isothermal amplification 有权

公开(公告)号：US11708613B2

公开(公告)日：2023-07-25

申请号：US16609994

申请日：2018-04-27

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Amanda E. Calvert

IPC分类号： C12Q1/6888 , C12Q1/70 , C12Q1/6844

CPC分类号： C12Q1/6888 , C12Q1/6844 , C12Q1/701 , C12Q2525/301 , C12Q2531/119 , C12Q2600/16

摘要： A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per μl and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.