公开(公告)号：US20050239811A1

公开(公告)日：2005-10-27

申请号：US11111581

申请日：2005-04-21

申请人： Todd Brugel ,  Jennifer Townes ,  Michael Clark ,  Mark Sabat ,  Adam Golebiowski ,  Biswanath De ,  Stephen Berberich ,  Gregory Bosch

发明人： Todd Brugel ,  Jennifer Townes ,  Michael Clark ,  Mark Sabat ,  Adam Golebiowski ,  Biswanath De ,  Stephen Berberich ,  Gregory Bosch

IPC分类号： A61K31/505 ,  C07D239/48 ,  C07D239/49 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

摘要翻译： 本发明涉及抑制炎性细胞因子细胞外释放的1,1,3-三取代脲，所述的所述细胞因子负责一个或多个人或更高的哺乳动物疾病状态。 本发明还涉及包含抑制炎性细胞因子的细胞外释放的所述1,1,3-三取代脲的组合物，以及用于预防，减轻或以其他方式控制酶的方法，所述酶被理解为负责所述酶的活性成分 这里描述了疾病状态。

公开(公告)号：US20070299120A1

公开(公告)日：2007-12-27

申请号：US11765359

申请日：2007-06-19

申请人： John Janusz ,  Stephen Hodson ,  Gregory Bosch ,  Ronald White ,  Benjamin Blass ,  Christopher Jackson ,  Neil Fairweather

发明人： John Janusz ,  Stephen Hodson ,  Gregory Bosch ,  Ronald White ,  Benjamin Blass ,  Christopher Jackson ,  Neil Fairweather

IPC分类号： A61K31/4166 ,  A61P9/06 ,  C07D233/32

CPC分类号： C07D233/38

摘要： The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

摘要翻译： 本发明涉及作为提供心房选择性抗心律失常药物的Kv1.5钾通道抑制剂有效的1-N-氨基-2-咪唑啉酮及其衍生物。 本发明还涉及包含所述Kv1.5钾通道抑制剂的组合物，以及用于治疗心律失常的方法。

公开(公告)号：US20060268410A1

公开(公告)日：2006-11-30

申请号：US11457212

申请日：2006-07-13

申请人： Bradley Busscher ,  Bradley Northman ,  Kenton Ypma ,  Randall Beute ,  John Roberts ,  Wayne Jordan ,  Edward DeNave ,  Daniel Bostwick ,  Randall Braun ,  Gregory Bosch ,  Timothy Bonardi

发明人： Bradley Busscher ,  Bradley Northman ,  Kenton Ypma ,  Randall Beute ,  John Roberts ,  Wayne Jordan ,  Edward DeNave ,  Daniel Bostwick ,  Randall Braun ,  Gregory Bosch ,  Timothy Bonardi

IPC分类号： G02B5/12

CPC分类号： B60R1/0602 ,  B60Q1/2665 ,  B60R1/07 ,  B60R1/072 ,  B60R1/088 ,  B60R1/1207 ,  B60R2001/1215 ,  G02B5/08 ,  H05K1/02 ,  H05K1/18 ,  H05K1/189 ,  H05K3/0058 ,  H05K2201/09072 ,  H05K2201/09081 ,  H05K2201/10106 ,  H05K2201/10484

摘要： A mirror assembly includes a housing, an angularly adjustable power pack, wires for supplying power and mirror angle control, an electrochromic mirror subassembly including a heater, and a turn signal device. The components include individual connectors that plug into a multi-prong connector on the bundle of wires, or that piggyback into each other. Optionally, the heater incorporates an internal wire with end connectors for communicating power to opposite sides of the heater, and also includes layers of light-transmitting/diffusing material for diffusing light passing from the turn signal device through the diffusing material. A printed circuit board fits into a pocket in the panel-shaped carrier, and an integral retainer releasably secures the printed circuit board. The power pack is attached to the carrier via a ring of resilient fingers, and a continuous hoop flange prevents distortion of the carrier and in turn of the glass elements in the mirror subassembly.

摘要翻译： 反射镜组件包括壳体，角度可调节的电源组，用于供电和镜角控制的电线，包括加热器的电致变色镜子组件和转向信号装置。 这些组件包括插入电线束上的多插头连接器或彼此搭载的单独连接器。 可选地，加热器包括具有端部连接器的内部导线，用于将功率传递到加热器的相对侧，并且还包括用于漫射从转向信号装置通过扩散材料的光的透光/扩散材料层。 印刷电路板装配在面板形载体中的凹槽中，并且整体的保持器可释放地固定印刷电路板。 电源组通过一个弹性手指环连接到载体上，连续的环形凸缘可防止载体和反射镜组件中的玻璃元件的变形。

公开(公告)号：US20060072202A1

公开(公告)日：2006-04-06

申请号：US11143233

申请日：2005-06-02

申请人： Timothy Bonardi ,  Randall Beute ,  Randall Braun ,  Bradley Busscher ,  Kenton Ypma ,  Gregory Bosch ,  Edward DeNave ,  Daniel Bostwick ,  Wayne Jordan ,  John Roberts

发明人： Timothy Bonardi ,  Randall Beute ,  Randall Braun ,  Bradley Busscher ,  Kenton Ypma ,  Gregory Bosch ,  Edward DeNave ,  Daniel Bostwick ,  Wayne Jordan ,  John Roberts

IPC分类号： G02B5/08

CPC分类号： B60R1/0602 ,  B60Q1/2665 ,  B60R1/07 ,  B60R1/072 ,  B60R1/088 ,  B60R1/1207 ,  B60R2001/1215 ,  G02B5/08 ,  H05K1/02 ,  H05K1/18 ,  H05K1/189 ,  H05K3/0058 ,  H05K2201/09072 ,  H05K2201/09081 ,  H05K2201/10106 ,  H05K2201/10484

摘要： A mirror assembly includes a housing, an angularly adjustable power pack, wires for supplying power and mirror angle control, an electrochromic mirror subassembly including a heater, and a turn signal device. The components include individual connectors that plug into a multi-prong connector on the bundle of wires, or that piggyback into each other. Optionally, the heater incorporates an internal wire with end connectors for communicating power to opposite sides of the heater, and also includes layers of light-transmitting/diffusing material for diffusing light passing from the turn signal device through the diffusing material. A printed circuit board fits into a pocket in the panel-shaped carrier, and an integral retainer releasably secures the printed circuit board. The power pack is attached to the carrier via a ring of resilient fingers, and a continuous hoop flange prevents distortion of the carrier and in turn of the glass elements in the mirror subassembly.

公开(公告)号：US20090169646A1

公开(公告)日：2009-07-02

申请号：US12280486

申请日：2007-02-22

申请人： Gregory Bosch ,  Claire Sampson

发明人： Gregory Bosch ,  Claire Sampson

IPC分类号： A61K33/00

CPC分类号： A61K9/0078 ,  A61K33/20 ,  A61K45/06

摘要： A method of treating and/or managing cystic fibrosis in a patient by administering an electrolyzed saline solution containing hypohalous acid. Preferably, the hypohalous acid is hypochlorous acid. Also provided is a method of treating and/or managing cystic fibrosis by administering an electrolyzed saline solution at specific pHs such as between 5.0 and 6.2. The present invention also provides a method of administering an electrolyzed saline solution for treating and/or managing cystic fibrosis using a combined electrochemical generator and a vaporizer, humidifier or fogger. Combination therapies are also provided.

摘要翻译： 通过施用含有次卤酸的电解盐水溶液来治疗和/或治疗患者的囊性纤维化的方法。 优选地，次卤酸是次氯酸。 还提供了通过在特定pH（例如5.0至6.2）之间施用电解盐水溶液来治疗和/或治疗囊性纤维化的方法。 本发明还提供了一种使用组合的电化学发生器和蒸发器，加湿器或喷雾器来施用电解盐水溶液以治疗和/或治疗囊性纤维化的方法。 还提供组合疗法。

公开(公告)号：US20060122248A1

公开(公告)日：2006-06-08

申请号：US11332998

申请日：2006-01-17

申请人： Jared Randall ,  Richard Gibbs ,  Gregory Bosch ,  Michael Curtis ,  Li Sun ,  Nicholas Nikolaides

发明人： Jared Randall ,  Richard Gibbs ,  Gregory Bosch ,  Michael Curtis ,  Li Sun ,  Nicholas Nikolaides

IPC分类号： A61K31/4184 ,  C07D403/02

CPC分类号： C07D235/06

摘要： 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

摘要翻译： 6 - [（4,5-二氢-1H-咪唑-2-基）氨基] -7-甲基-1H-苯并咪唑-4-甲腈基本上不含2,3,7-三氨基-4,6-二甲基 - 1,9-吩嗪腈和其无水单乙酸盐可用于治疗α-2介导的病症如高眼压症。