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公开(公告)号：US09161976B2
公开(公告)日：2015-10-20
申请号：US13657032
申请日：2012-10-22
发明人： Randolph J. Noelle , Cory L. Ahonen , Ross M. Kedl
IPC分类号： A61K39/02 , A61K39/12 , A61K38/19 , A61K48/00 , A61K39/395 , A61K31/4745 , A61K39/39 , A61K45/06 , A61K38/16 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10 , A61K39/00
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10 , A61K38/164 , A61K39/0002 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/585 , A61K2300/00
摘要： The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
摘要翻译： 本发明提供免疫刺激组合。 通常，免疫刺激组合包括TLR激动剂和TNF / R激动剂。 某些免疫刺激组合也可包括抗原。
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公开(公告)号：US10105426B2
公开(公告)日：2018-10-23
申请号：US14850529
申请日：2015-09-10
发明人： Randolph J. Noelle , Cory L. Ahonen , Ross M. Kedl
IPC分类号： A61K39/02 , A61K39/12 , A61K38/19 , A61K39/395 , A61K39/00 , A61K31/4745 , A61K39/39 , A61K45/06 , A61K38/16 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10
摘要： The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
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公开(公告)号：US20160129095A1
公开(公告)日：2016-05-12
申请号：US14850529
申请日：2015-09-10
发明人： Randolph J. NOELLE , Cory L. Ahonen , Ross M. Kedl
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10 , A61K38/164 , A61K39/0002 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/585 , A61K2300/00
摘要： The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
摘要翻译： 本发明提供免疫刺激组合。 通常，免疫刺激组合包括TLR激动剂和TNF / R激动剂。 某些免疫刺激组合也可包括抗原。
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公开(公告)号：US20130115228A1
公开(公告)日：2013-05-09
申请号：US13657032
申请日：2012-10-22
发明人： Randolph J. Noelle , Cory L. Ahonen , Ross M. Kedl
IPC分类号： A61K39/395 , A61K31/5377 , A61K38/08 , A61K31/739 , A61K31/7115 , A61K38/10 , A61K31/4745 , A61K31/7084
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/5377 , A61K31/7084 , A61K31/7115 , A61K31/739 , A61K38/08 , A61K38/10 , A61K38/164 , A61K39/0002 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/585 , A61K2300/00
摘要： The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
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公开(公告)号：US09801947B2
公开(公告)日：2017-10-31
申请号：US14507139
申请日：2014-10-06
发明人： Richard L. Miller , Mark A. Tomai , Ross M. Kedl , Isidro Angelo Eleazar Zarraga , Ronnie Ortiz , James D. Stoesz , Paul D. Wightman
CPC分类号： A61K47/6911 , A61K31/44 , A61K39/00 , A61K39/39 , A61K47/543 , Y02A50/41 , Y02A50/488 , Y02A50/489
摘要： Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
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公开(公告)号：US20150044279A1
公开(公告)日：2015-02-12
申请号：US14507139
申请日：2014-10-06
发明人： Richard L. Miller , Mark A. Tomai , Ross M. Kedl , Isidro Angelo Eleazar Zarraga , Ronnie Ortiz , James D. Stoesz , Paul D. Wightman
CPC分类号： A61K47/6911 , A61K31/44 , A61K39/00 , A61K39/39 , A61K47/543 , Y02A50/41 , Y02A50/488 , Y02A50/489
摘要： Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
摘要翻译： 通过在局部组织区域内沉积IRM贮库制剂来提供IRM化合物的免疫应答的方法和组合物，其提供活性IRM在局部组织区域内延长的停留时间。
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