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公开(公告)号：US20180155410A1
公开(公告)日：2018-06-07
申请号：US15828260
申请日：2017-11-30
申请人： Thomas Julius Borody
发明人： Thomas Julius Borody
CPC分类号： C07K16/02 , A61K35/74 , A61K2039/505 , C07K16/1282 , C07K2317/11 , Y02A50/489 , Y02A50/49 , A61K2300/00
摘要： A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing or reducing the likelihood of enteric pathogen infections in animals at risk for developing such infections.
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公开(公告)号：US20170319712A1
公开(公告)日：2017-11-09
申请号：US15661705
申请日：2017-07-27
发明人： RICHARD L. MILLER , MARK A. TOMAI , ROSS M. KEDL , ISIDRO ANGELO ELEAZAR ZARRAGA , RONNIE ORTIZ , JAMES D. STOESZ , PAUL D. WIGHTMAN
CPC分类号： A61K47/6911 , A61K31/44 , A61K39/00 , A61K39/39 , A61K47/543 , Y02A50/41 , Y02A50/488 , Y02A50/489
摘要： Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
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公开(公告)号：US20170281757A1
公开(公告)日：2017-10-05
申请号：US15468961
申请日：2017-03-24
申请人： NESTEC S.A.
IPC分类号： A61K39/395 , A23L33/135 , A61K35/747 , A61K35/741 , A61K35/745 , A23L33/00 , A61K35/744
CPC分类号： A61K39/395 , A23L33/135 , A23L33/40 , A23V2002/00 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Ways to increase the effectiveness of probiotics are disclosed. One embodiment relates to a combination of probiotics with secretory IgA and possible uses of this combination. For example, a method of using a composition containing secretory IgA and at least one probiotic to prepare a product to treat or prevent infection is disclosed.
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公开(公告)号：US20170224616A1
公开(公告)日：2017-08-10
申请号：US15495066
申请日：2017-04-24
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412 , Y02A50/489
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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5.发明授权公开(公告)号：US09603915B2
公开(公告)日：2017-03-28
申请号：US14768011
申请日：2014-02-14
发明人： John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号： A61K39/002 , A61K39/012 , C12N15/00 , A61K39/015 , C07K14/445 , A61K39/00
CPC分类号： A61K39/002 , A61K39/012 , A61K39/015 , A61K2039/523 , A61K2039/53 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55583 , C07K14/445 , Y02A50/489
摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or morality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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公开(公告)号：US09314517B2
公开(公告)日：2016-04-19
申请号：US12899507
申请日：2010-10-06
申请人： William J. Snell , Yanjie Liu , Oliver Billker , Robert E. Sinden , Rita Tewari
发明人： William J. Snell , Yanjie Liu , Oliver Billker , Robert E. Sinden , Rita Tewari
IPC分类号： A61K39/018 , A61K39/002 , A61K39/005 , A61K39/12 , A61K39/15 , C07K14/44 , A61K39/012 , A61K39/015 , A61K39/00
CPC分类号： A61K39/018 , A61K39/002 , A61K39/005 , A61K39/012 , A61K39/015 , A61K2039/55566 , A61K2039/55572 , C07K14/44 , Y02A50/412 , Y02A50/489
摘要： Compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream are disclosed herein.
摘要翻译： 本文公开了用于开发和使用疫苗的组合物和方法，所述疫苗包含适于触发人血液中的FusM特异性免疫应答的载体中的一种或多种FusM抗原。
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7.发明申请COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION 有权增强免疫应答对伊米诺病毒或限制艾滋病感染的组合物和方法公开(公告)号：US20160000895A1
公开(公告)日：2016-01-07
申请号：US14768011
申请日：2014-02-14
发明人： John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号： A61K39/015 , A61K39/002
CPC分类号： A61K39/002 , A61K39/012 , A61K39/015 , A61K2039/523 , A61K2039/53 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55583 , C07K14/445 , Y02A50/489
摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or morality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
摘要翻译： 本文提供疫苗载体和使用疫苗载体增强对Apicomplexan寄生虫的免疫应答并降低与随后感染相关的发病率或道德的方法。 疫苗载体包括编码菱形多肽的多核苷酸，任选地包括在疫苗载体的表面上适当表达的免疫刺激性多肽。
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公开(公告)号：US20120177650A1
公开(公告)日：2012-07-12
申请号：US13497118
申请日：2010-09-22
申请人： Thomas Julius Borody
发明人： Thomas Julius Borody
IPC分类号： A61K39/395 , A61K39/42 , A61P31/00 , A61P31/04 , A61P1/12 , A61P31/10 , A61P33/00 , A61P31/14 , A61P31/20 , A61P1/00 , A61K39/40 , A61P31/12
CPC分类号： C07K16/02 , A61K35/74 , A61K2039/505 , C07K16/1282 , C07K2317/11 , Y02A50/489 , Y02A50/49 , A61K2300/00
摘要： A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing or reducing the likelihood of enteric pathogen infections in animals at risk for developing such infections.
摘要翻译： 用于治疗患有这种感染或显示与这种感染相一致的疾病或病症的动物的肠道病原体感染的方法和组合物，或用于预防或降低发生这种感染风险的动物中肠道病原体感染的可能性。
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公开(公告)号：US20120141526A1
公开(公告)日：2012-06-07
申请号：US11929275
申请日：2007-10-30
申请人： James R. Baker , Anna Bielinska , Andrzej Myc
发明人： James R. Baker , Anna Bielinska , Andrzej Myc
IPC分类号： A61K39/21 , A61K39/12 , A61K39/02 , A61K39/07 , A61K39/145 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , A61P31/18 , A61K39/00 , A61P37/04 , B82Y5/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
摘要翻译： 本发明提供了用于刺激免疫应答的方法和组合物。 具体地，本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。 因此，在一些实施方案中，本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。 因此，本发明提供了针对各种环境和人释放的病原体的改进的疫苗。
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公开(公告)号：US20110171267A1
公开(公告)日：2011-07-14
申请号：US13014431
申请日：2011-01-26
CPC分类号： A61K39/0002 , A61K2039/521 , Y02A50/41 , Y02A50/489
摘要： A multivalent fungal vaccine comprising one or more heat-inactivated fungal antigens, wherein at least one fungal antigen is effective in producing an immune response in a host when said vaccine is administered orally at a dose that is sufficient for preventing or treating the fungal disease in said host. Also described are methods for making and using an orally available anti-fungal vaccine.
摘要翻译： 包含一种或多种热灭活的真菌抗原的多价真菌疫苗，其中当所述疫苗以足以预防或治疗真菌病的剂量口服给药时，至少一种真菌抗原在宿主中产生免疫应答是有效的 主持人说。 还描述了制备和使用口服可用的抗真菌疫苗的方法。
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