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    Aptamer Conjugates with N-Heterocyclic Carbene Metal Complexes for Targeted Drug Delivery
    1.
    发明申请
    Aptamer Conjugates with N-Heterocyclic Carbene Metal Complexes for Targeted Drug Delivery 审中-公开

    公开(公告)号：US20200339993A1

    公开(公告)日：2020-10-29

    申请号：US16925545

    申请日：2020-07-10

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC: C12N15/115 ,  A61K47/54 ,  A61K31/555

    Abstract: An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery
    3.
    发明授权
    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery 有权

    公开(公告)号：US11912999B2

    公开(公告)日：2024-02-27

    申请号：US16925545

    申请日：2020-07-10

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC: C12N15/115 ,  A61K47/54 ,  A61K31/555

    CPC classification number: C12N15/115 ,  A61K31/555 ,  A61K47/549 ,  C12N2310/16 ,  C12N2310/351

    Abstract: An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

    Macrocyclic poly(akane)s and poly(alkane-co-alkene)s
    4.
    发明授权
    Macrocyclic poly(akane)s and poly(alkane-co-alkene)s 有权

    公开(公告)号：US11807694B2

    公开(公告)日：2023-11-07

    申请号：US16648159

    申请日：2018-08-24

    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    Inventor： Adam S. Veige

    IPC: C08F110/06 ,  C08F138/00 ,  C08F110/14 ,  C08G61/08

    CPC classification number: C08F110/06 ,  C08F110/14 ,  C08F138/00 ,  C08G61/08 ,  C08F2500/25 ,  C08G2261/418 ,  C08G2261/419 ,  C08G2261/724

    Abstract: Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(═CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(═CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

    Functionalized Cyclic Polymers and Methods of Preparing Same
    5.
    发明申请
    Functionalized Cyclic Polymers and Methods of Preparing Same 有权

    公开(公告)号：US20220056167A1

    公开(公告)日：2022-02-24

    申请号：US17516191

    申请日：2021-11-01

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Adam S. Veige

    IPC: C08F4/78

    Abstract: The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.

    MACROCYCLIC POLY(AKANE)S AND POLY(ALKANE-CO-ALKENE)S
    8.
    发明申请
    MACROCYCLIC POLY(AKANE)S AND POLY(ALKANE-CO-ALKENE)S 审中-公开

    公开(公告)号：US20200255560A1

    公开(公告)日：2020-08-13

    申请号：US16648159

    申请日：2018-08-24

    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    Inventor： Adam S. Veige

    IPC: C08F110/06 ,  C08G61/08 ,  C08F138/00 ,  C08F110/14

    Abstract: Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(═CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(═CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery
    9.
    发明授权
    Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery 有权

    公开(公告)号：US10731164B2

    公开(公告)日：2020-08-04

    申请号：US15397231

    申请日：2017-01-03

    Applicant: University of Florida Research Foundation, Inc.

    Inventor： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

    IPC: A61K35/35 ,  C12N5/077 ,  C12N15/115 ,  A61K47/54 ,  A61K31/555

    Abstract: An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.

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