专利检索 ap:("UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION" OR "THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN") AND inv:"Giorgio TRINCHIERI" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开

公开(公告)号：US20240041931A1

公开(公告)日：2024-02-08

申请号：US18266455

申请日：2021-12-10

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

发明人： Diwakar DAVAR , Hassane Mohamed ZAROUR , Giorgio TRINCHIERI , Amiran Kasanovich DZUTSEV

IPC分类号： A61K35/24 , A61K39/395 , A61K35/741 , A61P35/00

CPC分类号： A61K35/24 , A61K39/3955 , A61K35/741 , A61P35/00 , A61K2035/115

摘要： Disclosed herein are methods for treating cancer by administering an anti-PD-1 antibody and a fecal sample obtained from a donor that is responsive to an anti-PD-1 therapy. Specifically, the cancer comprising a melanoma, and a metastatic melanoma; and wherein the fecal sample comprises a higher level of bacteria of phylum Actinobacteria and/or phylum Firmicutes in comparison to a control.

2.

发明公开
COMPOSITIONS AND METHODS FOR DETERMINING RESPONSIVENESS TO IMMUNE CHECKPOINT INHIBITORS (ICI), INCREASING EFFECTIVENESS OF ICI, AND TREATING CANCER 审中-公开

公开(公告)号：US20240277778A1

公开(公告)日：2024-08-22

申请号：US18568661

申请日：2022-06-09

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN

发明人： Giorgio TRINCHIERI , Amiran Kasanovich DZUTSEV , John Anthony MCCULLOCH , Richard R. RODRIGUES , Diwakar DAVAR , Hassane Mohamed ZAROUR

IPC分类号： A61K35/741 , A61K39/00 , C07K16/28 , C12Q1/04

CPC分类号： A61K35/741 , C07K16/2818 , C12Q1/04 , A61K2039/505 , C07K2317/76 , G01N2800/52

摘要： Disclosed herein are methods for treating cancer by administering an immune checkpoint inhibitor and modifying an amount of one or more bacteria in an intestine of the subject.