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公开(公告)号：US20180206466A1
公开(公告)日：2018-07-26
申请号：US15877510
申请日：2018-01-23
Applicant: University of South Carolina
Inventor： Vimala Kaza , Eleni Farmaki , Ioulia Chatzistamou , Hippokratis Kiaris
IPC: A01K67/033 , A01K67/02
CPC classification number: A01K67/033 , A01K67/02 , A01K2217/15 , A01K2227/105 , A01K2267/03
Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.
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公开(公告)号：US20200296942A1
公开(公告)日：2020-09-24
申请号：US16893853
申请日：2020-06-05
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Vimala Kaza , Eleni Farmaki , Ioulia Chatzistamou , Hippokratis Kiaris
IPC: A01K67/033 , A01K67/02
Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells, as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.
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公开(公告)号：US20190359700A1
公开(公告)日：2019-11-28
申请号：US16371386
申请日：2019-04-01
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： HIPPOKRATIS KIARIS , Eleni Farmaki , Iolia Chatzistamolu , Vimala Kaza
IPC: C07K16/24 , C07K16/30 , A61K45/06 , A61K39/395 , C12Q1/686
Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.
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Patent Agency Ranking
公开(公告)号：US11766033B2
公开(公告)日：2023-09-26
申请号：US16893853
申请日：2020-06-05
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Vimala Kaza , Eleni Farmaki , Ioulia Chatzistamou , Hippokratis Kiaris
IPC: G01N33/00 , A01K67/033 , A01K67/02
CPC classification number: A01K67/033 , A01K67/02 , A01K2217/15 , A01K2227/105 , A01K2267/03
Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells, as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.
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公开(公告)号：US11629186B2
公开(公告)日：2023-04-18
申请号：US16895407
申请日：2020-06-08
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Hippokratis Kiaris , Eleni Farmaki , Ioulia Chatzistamou , Vimala Kaza
Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.
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公开(公告)号：US10723794B2
公开(公告)日：2020-07-28
申请号：US16371386
申请日：2019-04-01
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： Hippokratis Kiaris , Eleni Farmaki , Ioulia Chatzistamou , Vimala Kaza
Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.
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公开(公告)号：US10709120B2
公开(公告)日：2020-07-14
申请号：US15877510
申请日：2018-01-23
Applicant: University of South Carolina
Inventor： Vimala Kaza , Eleni Farmaki , Ioulia Chatzistamou , Hippokratis Kiaris
IPC: A01K67/033 , A01K67/02
Abstract: A nonhuman animal cancer model is described. The animal model includes an animal of the genus Peromyscus and xenograft cancer cells implanted in the animal. Methods for utilizing the animal model can include evaluation of growth and development of cancer cells as well as evaluation of known and potential cancer treatment therapies. The animal model can be utilized to examine the efficacy of an anticancer therapy at the preclinical stage, can be utilized to screen potential cancer treatments in an individualized cancer treatment protocol, and can be utilized for identification of biomarkers associated with particular cancers and/or particular anticancer therapies, among other beneficial uses.
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公开(公告)号：US20160272702A1
公开(公告)日：2016-09-22
申请号：US15072643
申请日：2016-03-17
Applicant: University of South Carolina
Inventor： Hippokratis Kiaris , Eleni Farmaki , Ioulia Chatzistamou , Vimala Kaza
IPC: C07K16/24 , C12Q1/68 , C07K16/30 , A61K45/06 , A61K39/395
CPC classification number: C07K16/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/3015 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C12Q1/686 , C12Q2600/112
Abstract: Methods and materials for prevention of migration of breast cancer cells are described. Methods include inhibition of CCL8 activity in the area of the breast cancer cells. One method includes delivery of an anti-CCL8 antibody or an anti-CCL8 antibody expressing vector to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount. Another method includes inhibition of expression of CCL8 in a subject, for instance via silencing of the CCL8 gene.
Abstract translation: 描述了用于预防乳腺癌细胞迁移的方法和材料。 方法包括抑制乳腺癌细胞区域中的CCL8活性。 一种方法包括将抗CCL8抗体或抗CCL8抗体表达载体递送至包括乳腺癌细胞的区域，例如以有效量递送至有需要的受试者。 另一种方法包括抑制受试者中CCL8的表达，例如通过沉默CCL8基因。
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