公开(公告)号：US11478529B2

公开(公告)日：2022-10-25

申请号：US16815356

申请日：2020-03-11

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Guangping Gao ,  Manas Kumar Santra ,  Sanchita Bhatnagar

IPC: A61K38/17 ,  A61K35/12 ,  A61K38/16 ,  A61K48/00 ,  C12N9/08

Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.

公开(公告)号：US20220186227A1

公开(公告)日：2022-06-16

申请号：US17439439

申请日：2020-03-28

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Dong-Hwan Kim

IPC: C12N15/113 ,  C07K14/72 ,  C12N15/11

Abstract: Compositions and methods for treating cancers containing an oncogenic KRAS mutant.

公开(公告)号：US20160206693A1

公开(公告)日：2016-07-21

申请号：US15074714

申请日：2016-03-18

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Guangping Gao ,  Manas Kumar Santra ,  Sanchita Bhatnagar

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K35/12 ,  A61K38/16 ,  A61K48/00 ,  A61K48/005 ,  C12N9/0065

Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.

Abstract translation: 治疗受试者的肿瘤的方法包括鉴定具有肿瘤风险或怀疑具有肿瘤的受试者，并向受试者施用有效量的SRPX。

公开(公告)号：US11873494B2

公开(公告)日：2024-01-16

申请号：US17406441

申请日：2021-08-19

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang

IPC: C07K14/47 ,  C12N15/113 ,  A61K45/06

CPC classification number: C12N15/1137 ,  C07K14/47 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/14

Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).

公开(公告)号：US20230416779A1

公开(公告)日：2023-12-28

申请号：US18311367

申请日：2023-05-03

Applicant: University of Massachusetts

Inventor： Miguel Sena Esteves ,  Guangping Gao ,  Michael R. Green ,  Dan Wang ,  Tessa Mercedes Simone

IPC: C12N15/86 ,  C07K14/47

CPC classification number: C12N15/86 ,  C07K14/4702 ,  C12N2750/14143 ,  C12N2310/141 ,  C12N2330/10 ,  C07K2319/41

Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.

公开(公告)号：US20210317529A9

公开(公告)日：2021-10-14

申请号：US16897549

申请日：2020-06-10

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

公开(公告)号：US11124795B2

公开(公告)日：2021-09-21

申请号：US16487876

申请日：2018-02-14

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang

IPC: C07K14/47 ,  C12N15/113 ,  A61K45/06

Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).

公开(公告)号：US12281308B2

公开(公告)日：2025-04-22

申请号：US17265466

申请日：2019-08-29

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang

IPC: A61K31/4409 ,  A61K31/472 ,  A61K31/505 ,  A61K31/551 ,  C12N15/113

Abstract: Methods that include inhibition of ROCK1/2 and other protein kinases to treat Friedreich Ataxia.

公开(公告)号：US11680275B2

公开(公告)日：2023-06-20

申请号：US16619733

申请日：2018-06-06

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Miguel Sena Esteves ,  Guangping Gao ,  Michael R. Green ,  Dan Wang ,  Tessa Mercedes Simone

IPC: C12N15/86 ,  C07K14/47

CPC classification number: C12N15/86 ,  C07K14/4702 ,  C07K2319/41 ,  C12N2310/141 ,  C12N2330/10 ,  C12N2750/14143

Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.

公开(公告)号：US20220226364A1

公开(公告)日：2022-07-21

申请号：US17714349

申请日：2022-04-06

Applicant: University of Massachusetts

Inventor： Peter L. Jones ,  Michael R. Green

IPC: A61K31/7105 ,  A61K45/06 ,  C12N15/113 ,  C12N15/90 ,  A61K31/713

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).