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公开(公告)号：US20050020576A1
公开(公告)日：2005-01-27
申请号：US10807113
申请日：2004-03-23
申请人： Wei Zhang , Alan Maycock , Michael Marella , Virendra Kumar , Forrest Gaul , Michael Chang , Deqi Guo
发明人： Wei Zhang , Alan Maycock , Michael Marella , Virendra Kumar , Forrest Gaul , Michael Chang , Deqi Guo
IPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06 , A61K31/55 , A61K31/40 , A61K31/445
CPC分类号： C07D295/073 , A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D403/06
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIB-i, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。 式I，II，IIA，III，IIIA，IIIB，IIB-i，IV和IVA的化合物具有以下结构：其中R1，R2，R3，R4; X，X4，X5，X7，X9; Y，Z和n如说明书中所述。
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2.发明授权公开(公告)号：US06476063B2
公开(公告)日：2002-11-05
申请号：US09803976
申请日：2001-03-13
申请人： Wei Yuan Zhang , Alan L. Maycock , Anthony Michael Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Anthony Michael Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
IPC分类号： A61K3140
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.
摘要翻译： 提供了用抗瘙痒化合物预防或治疗瘙痒症的方法。式I，II，IIA，III，IIIA，IV和IVA的化合物具有以下结构：其中R1，R2，R3，R4; X，X4，X5，X7，X9; Y，Z和n如说明书中所述。
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3.发明授权公开(公告)号：US06492351B1
公开(公告)日：2002-12-10
申请号：US09803901
申请日：2001-03-13
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
IPC分类号： C07F9547
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： The compounds of formulae IIA, the structure: wherein R1, R2, and X4, X5, n are as described in the specification.
摘要翻译： 式IIA化合物，其结构式如下：其中R1，R2和X4，X5，n如说明书所述。
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4.发明授权公开(公告)号：US06486165B2
公开(公告)日：2002-11-26
申请号：US09803957
申请日：2001-03-13
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
IPC分类号： A61K31495
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formula I
摘要翻译： 提供了用抗瘙痒化合物预防或治疗瘙痒症的方法。式I化合物
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公开(公告)号：US06303611B1
公开(公告)日：2001-10-16
申请号：US09150369
申请日：1998-09-09
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
IPC分类号： A61K31495
CPC分类号： C07D403/06 , A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula having the structure: wherein R1, R2, and X Y, Z, Ar and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。具有以下结构的式的化合物：其中R 1，R 2和X Y，Z，Ar和n如说明书中所述。
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公开(公告)号：US06391910B1
公开(公告)日：2002-05-21
申请号：US09478482
申请日：2000-01-06
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
IPC分类号： A61K3140
CPC分类号： C07D403/06 , A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物和含有它们的组合物以及将其用作镇痛药的方法。式I，II，IIA，III，IIIA，IV和IVA的化合物具有以下结构：其中R1，R2，R3，R4; X，X4，X5，X7，X9; Y，Z和n如说明书中所述。
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7.发明授权Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith 有权卡帕激动剂化合物药物制剂及其预防和治疗瘙痒的方法公开(公告)号：US06239154B1
公开(公告)日：2001-05-29
申请号：US09372191
申请日：1999-08-11
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , Deqi Guo
IPC分类号： A61K3144
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.
摘要翻译： 通过向患者施用类别的芳基乙酰胺类的抗瘙痒化合物或其药学上可接受的盐，例如具有结构式I，II，IIA，III，IV和IVA的化合物，用于预防或治疗瘙痒的方法， ：其中R1-4，X，X4，X5，X7，X9，Y和Z如说明书所述。
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8.发明授权Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith 失效卡帕激动剂化合物药物制剂及其预防和治疗瘙痒的方法
公开(公告)号：US6057323A
公开(公告)日：2000-05-02
申请号：US183011
申请日：1998-10-30
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
IPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06 , A61K31/495
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compound of formula I, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X; and ArY, Z and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂和抗瘙痒剂的方法。 具有以下结构的式I化合物：其中R1，R2; X; Ar Y，Z和n如说明书中所述。
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9.发明授权Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith 失效卡帕激动剂化合物药物制剂及其预防和治疗瘙痒的方法
公开(公告)号：US6054445A
公开(公告)日：2000-04-25
申请号：US307387
申请日：1999-05-07
申请人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
发明人： Wei Yuan Zhang , Alan L. Maycock , Michael Anthony Marella , Virendra Kumar , Forrest Gaul , An-Chih Chang , Deqi Guo
IPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06 , A61K31/675 , A61K31/40
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D295/073 , C07D403/06
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X.sub.4, X.sub.5 ; andAr and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂和抗瘙痒剂的方法。 具有以下结构的式IIA化合物：其中R1，R2; X4，X5; Ar和n如说明书中所述。
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公开(公告)号：US06750216B2
公开(公告)日：2004-06-15
申请号：US10146693
申请日：2002-05-15
IPC分类号： A61K3144
CPC分类号： C07D295/073 , A61K31/404 , A61K31/4439 , A61K45/06 , C07D207/12 , C07D209/42 , C07D213/56 , C07D241/04 , C07D403/06
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2, R, Ar and n are as described in the specification.
摘要翻译： 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。 式IIIB的化合物具有以下结构：其中R1，R2，R，Arand n如说明书中所述。
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